Search results: 232,008 results (approx.)

1. Interactions of C. frondosa-derived inhibitory peptides against angiotensin I-converting enzyme (ACE), α-amylase and lipase.

The study illustrates the molecular mechanisms by which marine-derived peptides exhibited different structures and inhibition functions to concurrently inhibit multiple enzymes involved in chronic diseases. Peptides (2 mg/mL) exhibited inhibition against angiotensin-converting enzyme (ACE,...

Author(s) : Zhang Yi; He ShuDong; Rui Xin; Simpson, B. K.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.367 ref.31

2. Plant cell cultures of Nordic berry species: phenolic and carotenoid profiling and biological assessments.

Plant cell cultures from cloudberry (CL), lingonberry (LI), stone berry (ST), arctic bramble (AB), and strawberry (SB) were studied in terms of their polyphenol and carotenoid composition, antioxidant activity, antihemolytic activity and cytotoxicity effects on cancerous cells. High-resolution mass ...

Author(s) : Rischer, H.; Nohynek, L.; Puupponen-Pimiä, R.; Aguiar, J.; Rocchetti, G.; Lucini, L.; Câmara, J. S.; Cruz, T. M.; Marques, M. B.; Granato, D.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.366

3. Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans.

Protein aggregation causes intracellular changes in neurons, which elicit signals to modulate proteostasis in the periphery. Beyond the nervous system, a fundamental question is whether other organs also communicate their proteostasis status to distal tissues. Here, we examine whether proteostasis...

Author(s) : Calculli, G.; Lee HyunJu; Shen KoNing; Pham, U.; Herholz, M.; Trifunovic, A.; Dillin, A.; Vilchez, D.

Publisher : American Association for the Advancement of Science, Washington, USA

Journal article : Science Advances 2021 Vol.7 No.26 ref.60

4. Ginsenoside Rb1 attenuates microglia activation to improve spinal cord injury via microRNA-130b-5p/TLR4/NF-κB axis.

Ginsenoside Rb1 (GRb1), a major ingredient of ginseng, has been found to be a potential protective agent in spinal cord injury (SCI) and in activated microglia-induced neuronal injury. This study discovered that GRb1 could facilitate miR-130b-5p expression in SCI rats and Toll-like receptor 4...

Author(s) : Wang Dan; Zhao ShiXin; Pan JunWei; Wang Zhen; Li Yu; Xu XiaoXiao; Yang JiaHao; Zhang Xi; Wang YiSheng; Liu Ming

Publisher : Wiley, Hoboken, USA

Journal article : Journal of Cellular Physiology 2021 Vol.236 No.3 pp.2144-2155

5. Positive effect of Astragaloside IV on neurite outgrowth via talin-dependent integrin signaling and microfilament force.

Integrin plays a prominent role in neurite outgrowth by transmitting both mechanical and chemical signals. Integrin expression is closely associated with Astragaloside IV (AS-IV), the main component extracted from Astragali radix, which has a positive effect on neural-protection. However, the...

Author(s) : Wang YiFan; Zhou JingWen; Tang ChuanFeng; Yu Jia; Zhu Wen; Guo Jun; Wang Yue

Publisher : Wiley, Hoboken, USA

Journal article : Journal of Cellular Physiology 2021 Vol.236 No.3 pp.2156-2168

6. Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. The coronavirus 3-chymotrypsin-like protease (3CLpro) controls virus replication and is therefore considered a major target and promising opportunity for rational-based antiviral discovery with...

Author(s) : Vandyck, K.; Deval, J.

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Current Opinion in Virology 2021 Vol.49 pp.36-40

7. Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.

To explore the antioxidant capacity of citrus flavonoids under different evaluation systems, chemical and biological methods were engaged to determine the antioxidant abilities of flavanones and polymethoxyflavones. Results showed that flavanones exhibited good antioxidant activity, while...

Author(s) : Wang Yue; Jin Rong; Chen JieBiao; Cao JinPing; Xiao JianBo; Li Xian; Sun ChongDe

Publisher : Elsevier Ltd, Oxford, UK

Journal article; Conference paper : Food Chemistry 2021 Vol.365

8. Gender differences in acute toxicity, toxicokinetic and tissue distribution of amphotericin B liposomes in rats.

Amphotericin B (AmB), an effective polyene drug with broad spectrum antifungal activity, is used for serious fungal infections. Liposomal amphotericin B (LAmB) is a lipid dosage form, which has a significantly improved toxicity profile compared with conventional amphotericin B deoxycholate (DAmB)....

Author(s) : Wang Dong; Zhang Wei; Ju JieXi; Wang LuJia; Huang RuYu; Xu YanFang; Zhang HaiLin; Qi JinLong

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Toxicology Letters 2021 Vol.338 pp.78-84

9. Comprehensive evaluation of NAODESHENG by combining UPLC quantitative fingerprint and antioxidant activity.

The screening of marker compound is of great significance to the quality control of traditional Chinese medicine (TCM). One approach which combines fingerprint and biological evaluation has developed rapidly. Multi-wavelength fusion fingerprints and antioxidant activity screening are integrated in...

Author(s) : Liao JunCheng; Wu YunShan; Xu FangFang; Chen WeiYing; Zheng ZuoLiang; Han XiaoDong; Liu Bo; Wang ShuMei; Guo DeAn

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Journal of Pharmaceutical and Biomedical Analysis 2021 Vol.193

10. Antioxidant potential of some fruit extracts prepared with different solvents.

In this study, phenolic extracts of strawberry, red raspberry, sour cherry, and cornelian cherry were obtained using methanol, ethanol, 80% methanol, and 80% ethanol as extraction solvents. Total phenolic content and antioxidant activities (ferric reducing power, antioxidant activity in linoleic...

Foreign Title :Farklı çözücülerle hazırlanan bazı meyve ekstraktlarının antioksidan potansiyeli.

Author(s) : Köroğlu, D. G.; Süyünç, G.; Yildirim, R.; Turan, S.

Publisher : Igdir University, Igdir, Turkey

Journal article : Journal of the Institute of Science and Technology 2021 Vol.11 No.2 pp.1127-1139 ref.37

11. Nutrient composition and functional properties of black elderberry (Sambucus nigra L.).

Black elderberry (Sambucus nigra) is a plant species in the Adoxaceae family and native to Europe, Asia, North Africa and the USA. Black elderberry plant has the round-shaped, purple-black colored, 3-5 seeded, small fruits. The chemical structure of Sambucus species consists of major compounds,...

Foreign Title :Kara mürverin (Sambucus nigra L.) besinsel içeriği ve fonksiyonel özellikleri.

Author(s) : Aliç, B.; Olcay, N.; Demir, M. K.

Publisher : Igdir University, Igdir, Turkey

Journal article : Journal of the Institute of Science and Technology 2021 Vol.11 No.2 pp.1140-1153 ref.many

12. Total synthesis and antimalarial activity of 2-(p-hydroxybenzyl)-prodigiosins, isoheptylprodigiosin, and geometric isomers of tambjamine MYP1 isolated from marine bacteria.

Highly efficient and straightforward synthetic routes toward the first total synthesis of 2-(p-hydroxybenzyl)-prodigiosins (2-5), isoheptylprodigiosin (6), and geometric isomers of tambjamine MYP1 ((E/Z)-7) have been developed. The crucial steps involved in these synthetic routes are the...

Author(s) : Kancharla, P.; Li YueXin; Yeluguri, M.; Dodean, R. A.; Reynolds, K. A.; Kelly, J. X.

Publisher : American Chemical Society, Washington, USA

Journal article : Journal of Medicinal Chemistry 2021 Vol.64 No.12 pp.8739-8754

13. Rutaecarpine ameliorated high sucrose-induced Alzheimer's disease like pathological and cognitive impairments in mice.

High sucrose can induce tau hyperphosphorylation and cognitive dysfunction/memory impairment as observed in Alzheimer's disease (AD). Rutaecarpine, a specific (transient receptor potential vanilloid 1 [TRPV1]) agonist, is neuroprotective against high sucrose diet-induced impairment, but detailed...

Author(s) : Zhao Bin; Wang Yi; Liu Rui; Jia XiaoLi; Hu Nan; An XingWei; Zheng ChenGuang; Chen Chong; Sun HongTao; Chen Feng; Wang JingJing; Li XiaoHong

Publisher : Mary Ann Liebert, Inc., New Rochelle, USA

Journal article : Rejuvenation Research 2021 Vol.24 No.3 pp.181-190

14. Tectorigenin attenuates cognitive impairments in mice with chronic cerebral ischemia by inhibiting the TLR4/NF-κB signaling pathway.

This study aims to explore the effect of Tectorigenin in chronic cerebral ischemia (CCI)-induced cognitive impairment mice model. Cognitive impairment, hippocampal tissue histopathology, and myelin density in CCI mice were detected. HT22 cells were used to induce oxygen-glucose...

Author(s) : Feng Wei

Publisher : Taylor & Francis, Singapore, Singapore

Journal article : Bioscience, Biotechnology and Biochemistry 2021 Vol.85 No.7 pp.1665-1674

15. Structure-activity relationships of antityrosinase and antioxidant activities of cinnamic acid and its derivatives.

The related structure-activity relationships of cinnamic acid and its derivates have not been studied in details yet. Herein, antityrosinase and antioxidant activities of 18 compounds were evaluated. The results demonstrated that the substituents on the phenyl ring of cinnamic acid led to the...

Author(s) : Chen JianMin; Ran MengNan; Wang MeiXia; Liu XinYing; Liu SiWan; Yu Yue

Publisher : Taylor & Francis, Singapore, Singapore

Journal article : Bioscience, Biotechnology and Biochemistry 2021 Vol.85 No.7 pp.1697-1705

16. Fermented date residue extract mix containing gamma-aminobutyric acid augments the immune function of mouse splenocytes.

An extract of date (fruit of a palm tree) residue plus food-grade glutamate, acetic acid, and yeast extract (date residue extract mix, DREM) has been successfully fermented with using Lactobacillus brevis JCM 1059T to produce gamma-aminobutyric acid (GABA). Here, mouse splenocytes were found to be...

Author(s) : Hattori, K.; Yamamoto, Y.; Fujii, S.; Kumrungsee, T.; Hasegawa, M.; Yoshida, A.; Suzuki, T.; Sambongi, Y.

Publisher : Taylor & Francis, Singapore, Singapore

Journal article : Bioscience, Biotechnology and Biochemistry 2021 Vol.85 No.7 pp.1753-1758

17. Two new azaphilone pigments from Talaromyces albobiverticillius and their anti-inflammatory activity.

Two new azaphilone pigments, talaralbols A and B (3 and 7), along with five known azaphilone metabolites (1, 2, and 4-6), were isolated from the culture of Talaromyces albobiverticillius associated with the isopod Armadillidium vulgare. Their structures were elucidated by a combination of 1 D and 2 ...

Author(s) : Bai Wei; Jing LiLin; Guan QiuYan; Tan RenXiang

Publisher : Taylor & Francis, Abingdon, UK

Journal article : Journal of Asian Natural Products Research 2021 Vol.23 No.4 pp.325-332 ref.19

18. New chlorophenolic glycoside from Curculigo orchioides and their activities on 5α-reductase.

Two new chlorophenolic glucosides curculigines P (1) and Q (2), together with seven known compounds (3-9), were isolated from the dried rhizomes of Curculigo orchioides. Their structures were determined by spectroscopic methods including 1 D, 2 D NMR and MS. All the isolated compounds were...

Author(s) : Deng XueLi; Zheng RuiRong; Han ZhuZhen; Gu LiHua; Wang ZhengTao

Publisher : Taylor & Francis, Abingdon, UK

Journal article : Journal of Asian Natural Products Research 2021 Vol.23 No.4 pp.333-340 ref.14

19. Phytoestrogen constituents and estrogenic activity of Pueraria candollei var. mirifica callus and its extract preparation for removing cytotoxic constituents.

In vitro cultures of Pueraria candollei var. mirifica (PC) are a promising source of phytoestrogens, however, the estrogenic activity of PC callus has not been evaluated. In this study, the phytochemicals of PC callus were analyzed and compared with the estrogenic activities on MCF-7 cell...

Author(s) : Kraithong, W.; Juengsanguanpornsuk, W.; Krittanai, S.; Yusakul, G.; Putalun, W.

Publisher : Prince of Songkla University, Hat Yai, Thailand

Journal article : Songklanakarin Journal of Science and Technology 2021 Vol.43 No.3 pp.703-710 ref.many

20. Potential of Chlorella sp. exopolysaccharide as adjuvant for Mannheimia haemolytica A2 vaccine in rat model.

The potential of exopolysaccharides (EPS) extracted from Chlorella sp. as adjuvant for formalin-killed whole organism of Mannheimia haemolytica A2 (MhA2) vaccine was investigated. Chlorella sp. was cultured in F/2 media and EPS was extracted and characterized using GPC, FTIR and SEM, while its...

Author(s) : Kamaradin, I. H.; Suvik Assaw; Sheikh, H. I.; Wahid, M. E. A.

Publisher : Prince of Songkla University, Hat Yai, Thailand

Journal article : Songklanakarin Journal of Science and Technology 2021 Vol.43 No.3 pp.752-760 ref.45

21. Anti-inflammatory effect of Moringa oleifera lam. leaf extract on UVB-irradiated human keratinocytes.

Moringa oleifera Lam. has multiple biological properties that are applicable to developing cosmeceuticals. The objective of this study was to evaluate anti-inflammatory effects of M. oleifera on normal human keratinocytes. The anti-inflammatory effects of water extract and 50% ethanol extract of M. ...

Author(s) : Engsuwan, J.; Waranuch, N.; Limpeanchob, N.; Ingkaninan, K.

Publisher : Prince of Songkla University, Hat Yai, Thailand

Journal article : Songklanakarin Journal of Science and Technology 2021 Vol.43 No.3 pp.774-780 ref.23

22. Synthesis of novel isoflavone/benzo-δ-sultam hybrids as potential anti-inflammatory drugs.

A small series of novel isoflavone/benzo-δ-sultam hybrids was synthesised and evaluated as potential anti-inflammatory and neuroprotective drugs in LPS-activated BV2 microglia. The benzo-δ-sultam core was constructed in a two-step reaction by coupling 2-halobenzenesulfonamide derivatives with...

Author(s) : Mengheres, G.; Rice, C. R.; Olajide, O. A.; Hemming, K.

Publisher : Elsevier, Cambridge, UK

Journal article : Bioorganic & Medicinal Chemistry Letters 2021 Vol.34

23. Discovery of natural product ellagic acid as a potent CD73 and CD39 dual inhibitor.

The ATP-adenosine pathway has been recently identified as an attractive immune-oncology target and several drug candidates have been entered clinic trials. Inspired by the report of the first small-molecule CD73 inhibitor AB680, we describe the discovery of natural product ellagic acid as a dual...

Author(s) : Wang Yuan; Wang ChuanHao; Zhu YaZhao; Zhang YanMing; Chen BaoBao; Wu YueLin; Yao JianZhong; Miao ZhenYuan

Publisher : Elsevier, Cambridge, UK

Journal article : Bioorganic & Medicinal Chemistry Letters 2021 Vol.34

24. Novel BuChE-IDO1 inhibitors from sertaconazole: virtual screening, chemical optimization and molecular modeling studies.

In our effort towards the identification of novel BuChE-IDO1 dual-targeted inhibitor for the treatment of Alzheimer's disease (AD), sertaconazole was identified through a combination of structure-based virtual screening followed by MM-GBSA rescoring. Preliminary chemical optimization was performed...

Author(s) : Zhou You; Lu Xin; Du Chenxi; Liu YiJun; Wang YiFan; Hong KwonHo; Chen Yao; Sun HaoPeng

Publisher : Elsevier, Cambridge, UK

Journal article : Bioorganic & Medicinal Chemistry Letters 2021 Vol.34

25. Molecular docking and synthesis of caffeic acid analogous and its anti-inflammatory, analgesic and ulcerogenic studies.

A series of caffeic acid (CA) derivatives 7a-j were synthesized via etherification and coupling action and their chemical structures were elucidated spectroscopically. Motivated by the various biological activities displayed by CA derivatives such as anti-inflammatory, antiviral, anticancer and...

Author(s) : Al-Ostoot, F. H.; Zabiulla; Grisha, S.; Mohammed, Y. H. E.; Vivek, H. K.; Ara Khanum, S.

Publisher : Elsevier, Cambridge, UK

Journal article : Bioorganic & Medicinal Chemistry Letters 2021 Vol.33