Search results: 141,263 results (approx.)

1. Identification of novel antihypertensive peptides from wine lees hydrolysate.

Enzymatic-assisted extraction using Flavourzyme® has been demonstrated to be a useful methodology to obtain wine lees (WL) enriched in phenolic compounds and with enhanced antihypertensive activity. Nevertheless, taking into account that Flavourzyme® possess proteolytic activity, the release of...

Author(s) : Bravo, F. I.; Mas-Capdevila, A.; López-Fernández-Sobrino, R.; Torres-Fuentes, C.; Mulero, M.; Alcaide-Hidalgo, J. M.; Muguerza, B.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.366

2. Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans.

Protein aggregation causes intracellular changes in neurons, which elicit signals to modulate proteostasis in the periphery. Beyond the nervous system, a fundamental question is whether other organs also communicate their proteostasis status to distal tissues. Here, we examine whether proteostasis...

Author(s) : Calculli, G.; Lee HyunJu; Shen KoNing; Pham, U.; Herholz, M.; Trifunovic, A.; Dillin, A.; Vilchez, D.

Publisher : American Association for the Advancement of Science, Washington, USA

Journal article : Science Advances 2021 Vol.7 No.26 ref.60

3. Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. The coronavirus 3-chymotrypsin-like protease (3CLpro) controls virus replication and is therefore considered a major target and promising opportunity for rational-based antiviral discovery with...

Author(s) : Vandyck, K.; Deval, J.

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Current Opinion in Virology 2021 Vol.49 pp.36-40

4. The potential of calorie restriction and calorie restriction mimetics in delaying aging: focus on experimental models.

Aging is a biological process determined by multiple cellular mechanisms, such as genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular...

Author(s) : Giacomello, E.; Toniolo, L.

Publisher : MDPI AG, Basel, Switzerland

Journal article : Nutrients 2021 Vol.13 No.7 ref.156

5. Pancreatic β cells inhibit glucagon secretion from α cells: an in vitro demonstration of α-β cell interaction.

Interactions between endocrine and cells are critical to their secretory function in vivo. The interactions are highly regulated, although yet to be fully understood. In this study, we aim to assess the impact of and cell co-culture on hormone secretion. Mouse clonal cell lines -TC6-1 (cell line)...

Author(s) : Gu, W.; Anker, C. C. B.; Christiansen, C. B.; Tilo Moede; Per-olof Berggren; Hermansen, K.; Gregersen, S.; Jeppesen, P. B.

Publisher : MDPI AG, Basel, Switzerland

Journal article : Nutrients 2021 Vol.13 No.7 ref.49

6. Fermented milk modulates immune systemic response and intestinal epithelial structure in Balb/c mice sensitized to bovine whey proteins.

In epidemiological studies, cow's milk protein allergy (CMPA) is the most prevalent allergy for infants or young children. This study was conducted to compare the effect of Soummam and Saifi fermented milks on mice sensiti-zed to whey protein (β -Lactoglobulin and α -Lactalbumin). During 28 days,...

Author(s) : Yamina, B.; Samia, A.; Wafaa, D.; Hafsia, A.; Mama, B.; Djamel, S.; Omar, K.

Publisher : Infofacility, Ghaziabad, India

Journal article : South Asian Journal of Experimental Biology 2021 Vol.11 No.4 pp.400-406 ref.25

7. Tectorigenin attenuates cognitive impairments in mice with chronic cerebral ischemia by inhibiting the TLR4/NF-κB signaling pathway.

This study aims to explore the effect of Tectorigenin in chronic cerebral ischemia (CCI)-induced cognitive impairment mice model. Cognitive impairment, hippocampal tissue histopathology, and myelin density in CCI mice were detected. HT22 cells were used to induce oxygen-glucose...

Author(s) : Feng Wei

Publisher : Taylor & Francis, Singapore, Singapore

Journal article : Bioscience, Biotechnology and Biochemistry 2021 Vol.85 No.7 pp.1665-1674

8. Why do epidemiologic studies find an inverse association between intraprostatic inflammation and prostate cancer: a possible role for colliding bias?

Inflammation is an emerging risk factor for prostate cancer based largely on evidence from animal models and histopathologic observations. However, findings from patho-epidemiologic studies of intraprostatic inflammation and prostate cancer have been less supportive, with inverse associations...

Author(s) : Langston, M. E.; Sfanos, K. S.; Khan, S.; Nguyen, T. Q.; Marzo, A. M. de; Platz, E. A.; Sutcliffe, S.

Publisher : American Association for Cancer Research Inc., Philadelphia, USA

Journal article : Cancer Epidemiology, Biomarkers & Prevention 2021 Vol.30 No.2 pp.255-259

9. The effect of Electron beam on oxidative stress and inflammatory factors in diabetes mellitus: an in vitro and in vivo study.

Background: The main purpose of this study was to investigate whether or not electron beam therapy (EBT) was an effective method in terms of moderating oxidative stress by reducing free radicals in BALB/c mice with type 1 diabetes mellitus. Methods: The study was performed on thirty BALB/c mice in...

Author(s) : Martirosyan, D.; Shahnazari-Aval, M.; Ashoori, M. R.; Mikaeili, A. S.; Nakhjavani, M.; Mirmiranpour, H.

Publisher : Food Science Publisher, Denton, USA

Journal article : Functional Foods in Health and Disease 2021 Vol.11 No.7 pp.333-344 ref.49

10. Laser facilitated epicutaneous peptide immunization using dry patch technology.

The skin has been intensely investigated as a target tissue for immunization because it is populated by multiple types of antigen presenting cells. Directly addressing dendritic cells or Langerhans cells in vivo represents an attractive strategy for inducing T cell responses in cancer...

Author(s) : Scheiblhofer, S.; Drothler, S.; Braun, W.; Braun, R.; Boesch, M.; Weiss, R.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Vaccine 2021 Vol.39 No.37 pp.5259-5264

11. Detection of Schistosoma mansoni long non-coding RNAs in the infected C57BL/6 mouse liver.

Long non-coding RNAs (lncRNAs) perform several types of regulatory functions and have been recently explored in the genus Schistosoma. Although sequencing and bioinformatics approaches have demonstrated the presence of hundreds of lncRNAs and microRNAs (miRNAs) in this genus, information regarding...

Author(s) : Mota, E. A.; Oliveira, V. F. de; Patrocinio, A. B. do; Rodrigues, V.; Guerra-Sá, R.

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Experimental Parasitology 2021 Vol.222

12. Carnosine improves aging-induced cognitive impairment and brain regional neurodegeneration in relation to the neuropathological alterations in the secondary structure of amyloid beta (Aβ).

Aging-induced proteinopathies, including deterioration of amyloid beta (Aβ) conformation, are associated with reductions in endogenous levels of carnosine and cognitive impairments. Carnosine is a well-known endogenous antioxidant, which counteracts aging-induced Aβ plaque formation. The aim of...

Author(s) : Soumyabrata Banerjee; Biswajit Mukherjee; Poddar, M. K.; Dunbar, G. L.

Publisher : Wiley, Oxford, UK

Journal article : Journal of Neurochemistry 2021 Vol.158 No.3 pp.710-723

13. Body weight profile and mortality rate of male Sprague Dawley rats during the formation of fibrosarcoma induced by benzo(a)pyrene.

Benzo(a)pyrene (BaP) is one of several examples of polycyclic aromatic hydrocarbons that come from incomplete combustion of organic materials. BaP compound is used in research to induce fibrosarcoma.In general, patients with cancer will experience a reduction in body weight. This study aims to...

Foreign Title :Profil bobot badan dan tingkat mortalitas tikus jantan galur Sprague Dawley selama pembentukan fibrosarkoma yang dipicu oleh benzo(a)piren.

Author(s) : Adi, P. S. S.; Winaya, I. B. O.; Mirah, A. A. A.

Publisher : Fakultas Kedokteran Hewan, Universitas Udayana, Denpasar, Indonesia

Journal article : Indonesia Medicus Veterinus 2021 Vol.10 No.1 pp.1-11 ref.24

14. Molecular effects of curcumin on the experimental autoimmune encephalomyelitis.

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). Previous studies have shown that myelin degradation during MS and EAE resulted in reduced expression of some of the proteins, e.g., the MBP (myelin basic protein), and increased expression of genes such...

Author(s) : Mavaddatiyan, L.; Khezri, S.; Froushani, S. M. A.

Publisher : Urmia University, Faculty of Veterinary Medicine, Urmia, Iran

Journal article : Veterinary Research Forum 2021 Vol.12 No.1 pp.47-52 ref.45

15. Effects of liraglutide on sperm characteristics and fertilization potential following experimentally induced diabetes in mice.

The current study was conducted to analyze the dose-dependent effects of liraglutide against the diabetes-induced detrimental impact on sperm parameters and fertilization potential. For this purpose, 42 adult male mice were randomly divided into control (with no intervention) and experimental...

Author(s) : Pourheydar, M.; Hassanzadeh, S.; Razi, M.; Pourheydar, B.; Najafi, G.

Publisher : Urmia University, Faculty of Veterinary Medicine, Urmia, Iran

Journal article : Veterinary Research Forum 2021 Vol.12 No.1 pp.109-116 ref.49

16. Peiminine inhibits the progression of colorectal cancer through up-regulating miR-760 via declining the expression of long noncoding RNA LINC00659.

Colorectal cancer (CRC) is a commonly diagnosed type of cancer globally. The molecular mechanism by which peiminine suppressed the progression of CRC is not fully addressed. The viability was assessed through cell counting kit 8 assay. Colony formation assay was used to analyze the colony formation ...

Author(s) : Li JianFeng; Qin YeYu; Wang WeiJun; Yang Kai; Zhang Min

Publisher : Lippincott Williams & Wilkins, London, UK

Journal article : Anti-Cancer Drugs 2021 Vol.32 No.2 pp.148-156 ref.26

17. Immunological validation of the pharmacological and anti-allergic action of glycyrrhetinic acid from Glycyrrhizae radix.

Aim: Glycyrrhetinic acid (GA) is an important and active metabolite derived from glycyrrhizin (GL) in Glycyrrhizae Radix (GR) that induces anti-allergic, anti-inflammatory, anti-oxidant, anti-viral, and anti-microbial effects in vivo. To validate these beneficial actions of GA as an active compound ...

Author(s) : Hisaka, S.; Murase, S.; Kishi, H.; Nose, M.

Publisher : Wiley, Tokyo, Japan

Journal article : Traditional & Kampo Medicine 2021 Vol.8 No.2 pp.148-154 ref.14

18. Effect of electro-acupuncture at ST 36 on maternal food restriction-induced lung phenotype in rat offspring.

Maternal food restriction (MFR) during pregnancy leads to pulmonary dysplasia in the newborn period and increases susceptibility to diseases, such as asthma and chronic lung disease, later in life. Previous studies have shown that maternal electro-acupuncture (EA) applied to "Zusanli" (ST 36) could ...

Author(s) : Mou QiuJie; Ji Bo; Zhao GuoZhen; Liu YiTian; Sakurai, R.; Xie YaNa; Zhang Qin; Dai Jian; Lu YaWen; Ge YunPeng; Shi TianYu; Xu Shuang; Rehan, V. K.

Publisher : Wiley, Hoboken, USA

Journal article : Pediatric Pulmonology 2021 Vol.56 No.8 pp.2537-2545 ref.32

19. Bupropion improves biochemical parameters of ethanol exposure in rats.

Today, alcohol intake is a significant factor in many diseases primarily digestive system disorders. Despite dopamine agonists for helping to heal on alcohol-induced damages was known, the effects of bupropion on ethanol-induced varying biochemical parameters were not clarified completely. This...

Author(s) : Türeyen, A.

Publisher : Afyon Kocatepe University Faculty of Veterinary Medicine, Afyonkarahisar, Turkey

Journal article : Kocatepe Veterinary Journal 2021 Vol.14 No.3 pp.346-350 ref.23

20. Plasmodium vivax pre-erythrocytic stages and the latent hypnozoite.

Plasmodium vivax is the most geographically widespread malaria parasite on the planet. This is largely because after mosquito transmission, P. vivax sporozoites can invade hepatocytes and form latent liver stages known as hypnozoites. These persistent liver stages can activate weeks, months or even ...

Author(s) : Zanghi Gigliola; Vaughan, A. M.

Publisher : Elsevier Ireland Ltd, Shannon, Irish Republic

Journal article : Parasitology International 2021 Vol.85

21. An epitope-specific chemically defined nanoparticle vaccine for respiratory syncytial virus.

Respiratory syncytial virus (RSV) can cause severe respiratory disease in humans, particularly in infants and the elderly. However, attempts to develop a safe and effective vaccine have so far been unsuccessful. Atomic-level structures of epitopes targeted by RSV-neutralizing antibodies are now...

Author(s) : Zuniga, A.; Rassek, O.; Vrohlings, M.; Marrero-Nodarse, A.; Moehle, K.; Robinson, J. A.; Ghasparian, A.

Publisher : Nature Publishing Group, London, UK

Journal article : npj Vaccines 2021 Vol.6 No.85 ref.42

22. A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells.

An array of SARS-CoV-2 virus variants have been isolated, propagated and used in in vitro assays, in vivo animal studies and human clinical trials. Observations of working stocks of SARS-CoV-2 suggest that sequential propagation in Vero cells leads to critical changes in the region of the furin...

Author(s) : Funnell, S. G. P.; Afrough, B.; Baczenas, J. J.; Berry, N.; Bewley, K. R.; Bradford, R.; Florence, C.; Duff, Y. le; Lewis, M.; Moriarty, R. V.; Connor, S. L. O.; Osman, K. L.; Pullan, S.; Rashid, S.; Richards, K. S.; Stemple, K. J.; Knezevic, I.

Publisher : Nature Publishing Group, London, UK

Journal article : npj Vaccines 2021 Vol.6 No.83 ref.13

23. Environmental level bisphenol A accelerates alterations of the Reno-cardiac axis by the MAPK cascades in male diabetic rats: an analysis based on transcriptomic profiling and bioinformatics.

In humans and animal models, the kidneys and cardiovascular systems are negatively affected by BPA from the environment. It is considered that BPA have some potential estrogen-like and non-hormone-like properties. In this study, RNA-sequencing and its-related bioinformatics was used as the basic...

Author(s) : Wu Bin; Zhao QiangQiang; Li ZuoNeng; Min ZhiTeng; Shi MengDie; Nie XinMin; He QingNan; Gui Rong

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Environmental Pollution 2021 Vol.287

24. Interfacial interaction between benzo[a]pyrene and pulmonary surfactant: adverse effects on lung health.

Inhaled polycyclic aromatic hydrocarbons (PAHs) can directly interact with the lung surfactant (PS) lining of alveoli, thereby affecting the normal physiological functions of PS, which is a serious threat to lung health. In spite of the extensive study of benzo[a]pyrene (BaP, a representative of...

Author(s) : Cao Yan; Zhao Qun; Geng YingXue; Li YingJie; Huang JianHong; Tian SenLin; Ning Ping

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Environmental Pollution 2021 Vol.287

25. Auxiliary hypolipidemic effect of a combination of Pu'er tea extract, Pueraria lobata and hawthorn.

The differential auxiliary hypolipidemic effects of Pu'er tea extract, Pu'er tea polysaccharide extract, and Pu'er tea polyphenol extract compounded with a combination of Pueraria lobata and hawthorn were investigated on rats with high-fat diet-induced hyperlipidemia. The experimental rats were...

Author(s) : Tong YuJie; Zu XiaoDong

Publisher : Tianjin Food Research Institute Co. Ltd, Tianjin, China

Journal article : Food Research and Development 2021 Vol.42 No.9 pp.54-58 ref.21