Search results: 145,738 results (approx.)

1. A novel aqueous dimethyl trisulfide formulation is effective at low doses against cyanide toxicity in non-anesthetized mice and rats.

Background: Cyanide (CN) is a metabolic poison that is capable of intoxicating individuals through accidental or intentional means. With high concentration exposures, death can occur in minutes. In cases of mass casualty exposures, there is a need for a rapid-acting countermeasure capable of being...

Author(s) : Lippner, D. S.; Hildenberger, D. M.; Rhoomes, M. O.; Winborn, J. N.; Dixon, H.; McDonough, J.; Rockwood, G. A.

Publisher : Taylor & Francis, Abingdon, UK

Journal article : Clinical Toxicology 2022 Vol.60 No.1 pp.83-94 ref.73

2. Results of a 30-day safety assessment in young mice orally exposed to polystyrene nanoparticles.

Polystyrene nanoparticles (PSNPs) are a newly emerging pollutant in the natural environment. However, due to the lack of sufficient toxicological studies in mammals, the potential effects of PSNPs on human health remain largely undefined. Therefore, in this study, young mice aged four weeks old...

Author(s) : Xiao JunTing; Jiang XueJun; Zhou YuJian; Sumayyah, G.; Zhou LiXiao; Tu BaiJie; Qin QiZhong; Qiu JingFu; Qin Xia; Zou Zhen; Chen ChengZhi

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Environmental Pollution 2022 Vol.292 No.Part B

3. Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein response.

Di (2-ethylhexyl) phthalate (DEHP) is a hazardous chemical which is used as a plasticizer in the plastic products. Lycopene (LYC) is a carotenoid that has protective roles against cellular damage in different organs. The present study sought to explore the role of the interaction between mitophagy...

Author(s) : Zhao Yi; Li HuiXin; Luo Yu; Cui JiaGen; Talukder, M.; Li JinLong

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Environmental Pollution 2022 Vol.292 No.Part B ref.85

4. Effects of nano- and microplastics on kidney: physicochemical properties, bioaccumulation, oxidative stress and immunoreaction.

The potential toxicity of nanoplastics (NPs) and microplastics (MPs) has raised concerns. However, knowledge of the effects of NPs/MPs on the health of mammals is still limited. Here we investigated the alteration of the physicochemical properties of polystyrene NPs (PS-NPs: 50 nm) and MPs (PS-MPs: ...

Author(s) : Meng XueMei; Zhang JiaWei; Wang WenJing; Gonzalez-Gil, G.; Vrouwenvelder, J. S.; Li ZhenYu

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Chemosphere 2022 Vol.288 No.Part 3 ref.61

5. Potential of human helminth therapy for resolution of inflammatory bowel disease: the future ahead.

Inflammatory bowel disease (IBD) is associated with a dysregulated mucosal immune response in the gastrointestinal tract. The number of patients with IBD has increased worldwide, especially in highly industrialized western societies. The population of patients with IBD in North America is...

Author(s) : Arai, T.; Lopes, F.

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Experimental Parasitology 2022 Vol.232 ref.156

6. Microglial phagocytosis of polystyrene microplastics results in immune alteration and apoptosis in vitro and in vivo.

The remarkable increase in plastic usage and widespread microplastic (MP) pollution has emerged as a substantial concern today. Many recent studies have revealed MPs as potentially hazardous substances in mammals. Despite several reports on the impact of small MPs in the brain and behaviors in...

Author(s) : Kwon WookBong; Kim DaeHwan; Kim HeeYeon; Jeong SangWon; Lee SeGuen; Kim HyunChul; Lee YoungJae; Kwon MiKyung; Hwang JunSeong; Han JeeEun; Park JinKyu; Lee SungJun; Choi SeongKyoon

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Science of the Total Environment 2022 Vol.807 No.Part 2 ref.43

7. Facile formation of injectable quaternized chitosan/tannic acid hydrogels with antibacterial and ROS scavenging capabilities for diabetic wound healing.

The wound healing process of the diabetic wound is often hindered by excessive oxygen free radicals and infection. An ideal wound dressing should possess great reactive oxygen species (ROS) scavenging property and considerable antibacterial ability. In this study, we facilely constructed a novel...

Author(s) : Pan WenHao; Qi XiaoLiang; Xiang YaJing; You ShengYe; Cai ErYa; Gao Teng; Tong XianQin; Hu RongDang; Shen JianLiang; Deng Hui

Publisher : Elsevier Ltd, Oxford, UK

Journal article : International Journal of Biological Macromolecules 2022 Vol.195 pp.190-197 ref.49

8. Gestational exposure to high fat diets and bisphenol A alters metabolic outcomes in dams and offspring, but produces hepatic steatosis only in dams.

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. Perinatal development is a critical window for altered, lifelong health trajectory, and evidence supports the role of perinatal programming in chronic metabolic diseases. To examine the impact of diet and bisphenol ...

Author(s) : Marchlewicz, E.; McCabe, C.; Djuric, Z.; Hoenerhoff, M.; Barks, J.; Tang Lu; Song, P. X.; Peterson, K.; Padmanabhan, V.; Dolinoy, D. C.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Chemosphere 2022 Vol.286 No.Part 2 ref.96

9. Identification of novel antihypertensive peptides from wine lees hydrolysate.

Enzymatic-assisted extraction using Flavourzyme® has been demonstrated to be a useful methodology to obtain wine lees (WL) enriched in phenolic compounds and with enhanced antihypertensive activity. Nevertheless, taking into account that Flavourzyme® possess proteolytic activity, the release of...

Author(s) : Bravo, F. I.; Mas-Capdevila, A.; López-Fernández-Sobrino, R.; Torres-Fuentes, C.; Mulero, M.; Alcaide-Hidalgo, J. M.; Muguerza, B.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.366

10. CRISPR screen identified that UGT1A9 was required for bisphenols-induced mitochondria dyshomeostasis.

Exposure to bisphenols chemicals could cause various adverse health effects, including non-alcoholic fatty liver disease (NAFLD), which have been associated with cellular mitochondria stress. However, the biological mechanism underlying the mitochondria stress-mediated cell death by bisphenols was...

Author(s) : Tian MingMing; Xia Pu; Gou Xiao; Yan Lu; Yu HongXia; Zhang XiaoWei

Publisher : Elsevier Inc, Orlando, USA

Journal article : Environmental Research 2022 Vol.205 ref.62

11. EGCG inhibits growth of tumoral lesions on lip and tongue of K-ras transgenic mice through the notch pathway.

Epigallocatechin-3-gallate (EGCG), the main active ingredient of green tea, exhibits low toxic side effect and versatile bioactivities, and its anti-cancer effect has been extensively studied. Most of the studies used cancer cell lines and xenograft models. However, whether EGCG can prevent tumor...

Author(s) : Wei Hua; Ge Qi; Zhang LingYu; Xie Jing; Gan RuiHuan; Lu YouGuang; Zheng DaLi

Publisher : Elsevier, New York, USA

Journal article : Journal of Nutritional Biochemistry 2022 Vol.99 ref.78

12. Water-soluble caffeic acid-dopamine acid-base complex exhibits enhanced bactericidal, antioxidant, and anticancer properties.

Despite the highly potent biological characteristics, the poor water-solubility of caffeic acid (CA) limits its applications in various domains. Here, we present a facile approach, wherein CA has been treated with dopamine hydrochloride (Dopa. HCl) to obtain a water-soluble acid-base complex, which ...

Author(s) : Hemanjali Mude; Maroju, P. A.; Aniket Balapure; Ramakrishnan Ganesan; Dutta, J. R.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.374 ref.45

13. Antibacterial, antioxidant and anti-inflammatory PLCL/gelatin nanofiber membranes to promote wound healing.

Epigallocatechin-3-O-gallate (EGCG) is a green biomedical agent for promoting wound healing, which possess excellent antibacterial, antioxidant and anti-inflammatory activities. For improving the low bioavailability challenges of EGCG in vivo, we had successful created a low-cost and simple wound...

Author(s) : Li Ang; Li LinHui; Zhao Bin'an; Li XiaoTong; Liang WenCheng; Lang MeiDong; Cheng Biao; Li Jun

Publisher : Elsevier Ltd, Oxford, UK

Journal article : International Journal of Biological Macromolecules 2022 Vol.194 pp.914-923

14. Sophoridine attenuates vascular endothelial injury by regulating the Src/PI3K pathway: molecular modelling.

Vascular endothelial injury is a major cause of cardiovascular diseases. Conventional treatments have several limitations; we thus explored whether sophoridine could protect against tumor necrosis factor-alpha induced vascular endothelial injury. We evaluated the effects of sophoridine on cell...

Author(s) : Jin Lei; Mo Yun; Shi Nan; Li JinFeng; Yue ErLi; Fang Ming; Liu KangYong

Publisher : New Century Health Publishers, LLC, New Orleans, USA

Journal article : Current Topics in Nutraceutical Research 2022 Vol.20 No.1 pp.15-21 ref.23

15. Differential effects of different diets on depressive-like phenotypes in C57BL/JJmsSLc mice.

Identical mouse models tested using the same protocols in different laboratories can produce inconsistent results. Indeed, little information is available regarding suitable diets for mouse models of disease in the field of neuroscience. Thus, neuroscientists often select experimental diets based...

Author(s) : Takahashi, E.; Ono, E.

Publisher : Elsevier, New York, USA

Journal article : Physiology & Behavior 2022 Vol.243 ref.28

16. Sucrose solution concentration and the intermittent access induced consumption increase.

Animals fed ad libitum consume less of a preferred additional food with daily access than with access only once every few days. With 4% sucrose solution, rats can drink over twice as much in a day if they receive it every fourth day compared to daily access. These differences are maintained when...

Author(s) : Eikelboom, R.; Hewitt, R.; Adams, K. L.

Publisher : Elsevier, New York, USA

Journal article : Physiology & Behavior 2022 Vol.243 ref.28

17. Arsenic-fluoride co-exposure induced endoplasmic reticulum stress resulting in apoptosis in rat heart and H9c2 cells.

Exposure to arsenic (As) or fluoride (F) has been shown to cause cardiovascular disease (CVDs). However, evidence about the effects of co-exposure to As and F on myocardium and their mechanisms remain scarce. Our aim was to fill the gap by establishing rat and H9c2 cell exposure models. We...

Author(s) : Li Meng; Feng Jing; Cheng Ying; Dong NiSha; Tian XiaoLin; Liu PengHui; Zhao YanNan; Qiu YuLan; Tian FengJie; Lyu Yi; Zhao Qian; Wei CaiLing; Wang Meng; Yuan JiYu; Ying XiaoDong; Ren XueFeng

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Chemosphere 2022 Vol.288 No.Part 2 ref.43

18. Host-pathogen interactions: the role of Pseudomonas aeruginosa exotoxin a in modulation of Galleria mellonella immune response.

The role of Pseudomonas aeruginosa exotoxin A in the modulation of humoral immune response parameters in the hemolymph of Galleria mellonella larvae was investigated. Our results indicate that exoA can play a role of a virulence factor by inhibiting insect PO, lysozyme, and antibacterial activity...

Author(s) : Iwanski, B.; Andrejko, M.

Publisher : Elsevier, Amsterdam, Netherlands

Journal article : Journal of Invertebrate Pathology 2022 Vol.187 ref.36

19. Ferruginol prevents degeneration of dopaminergic neurons by enhancing clearance of α-synuclein in neuronal cells.

Lewy bodies are characteristic spherical inclusions in Parkinson's disease (PD) that are formed by α-synuclein fibrils. Ferruginol (Fer) is an amonomeric compound isolated from a traditional Chinese herb. Here, we show that Fer exerted potent neuroprotective effects in both in vitro and in vivo PD...

Author(s) : Wang XiaoHong; Cao GuiYun; Ding DongYi; Li Fei; Zhao XueSong; Wang JiaHua; Yang Yang

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Fitoterapia 2022 Vol.156 ref.32

20. Ghrelin attenuates transforming growth factor-β1-induced pulmonary fibrosis via the miR-125a-5p/Kruppel-like factor 13 axis.

Pulmonary fibrosis is a severe condition with limited therapeutic options and characterized by increased fibroblast activation and progressive accumulation of extracellular matrix. Ghrelin, a gastrointestinal hormone, has been reported to possess protective roles in lung diseases including...

Author(s) : Qiu Jing; Ma ChunLan; Dai WenJing; Fang EnRong; Li WanCheng; Yang Fan

Publisher : Elsevier, New York, USA

Journal article : Archives of Biochemistry and Biophysics 2022 Vol.715

21. Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB.

Cristacarpin is a novel prenylated pterocarpan that reportedly exhibits broad anti-cancer activity by enhancing endoplasmic reticulum stress. However, whether and how cristacarpin affects in-flammatory processes remain largely unknown. In the present study, the anti-inflammatory effect of...

Author(s) : Hwang SuJung; Oh WonKeun; Lee HoYoung; Lee HyoJong

Publisher : Elsevier Masson SAS, Issy-les-Moulineaux, France

Journal article : Biomedicine & Pharmacotherapy 2022 Vol.145 ref.32

22. Evaluation of antioxidant activity and histopathological changes occurred by the oral ingestion of CuO nanoparticles in monosodium urate crystal-induced hyperuricemic BALB/c mice.

Nanotechnology is an intensive branch of science due to the unique features of nano range particles (1-100 nm). Their nano size results in a high surface area of absorption when orally administered. Monosodium urate crystal excessive deposition causes a commonly known inflammatory disease called...

Author(s) : Kiyani, M. M.; Butt, M. A.; Hamza Rehman; Moheen Mustafa; Sajjad, A. G.; Shah, S. S. H.; Tariq Mahmood; Bokhari, S. A. I.

Publisher : Springer US, Philadelphia, USA

Journal article : Biological Trace Element Research 2022 Vol.200 No.1 pp.217-227 ref.45

23. Curcumin ameliorated the mercuric chloride induced depression and anxiety in female mice offspring.

In the present investigation, the effect of mercuric chloride on gestation and lactation periods in mice was studied. The animals were treated with 10 ppm of HgCl2 and its complications were evaluated by supplementing 150 and 300 ppm of curcumin, respectively. Results indicated that HgCl2 increased ...

Author(s) : Abu-Taweel, G. M.; Rudayni, H. A.

Publisher : Elsevier Inc, Orlando, USA

Journal article : Environmental Research 2022 Vol.204 No.Part B ref.74

24. Effect of 17β-trenbolone exposure during adolescence on the circadian rhythm in male mice.

The suprachiasmatic nucleus (SCN) is the main control area of the clock rhythm in the mammalian brain. It drives daily behaviours and rhythms by synchronizing or suppressing the oscillations of clock genes in peripheral tissue. It is an important brain tissue structure that affects rhythm...

Author(s) : Zhang ShaoZhi; Feng XiZeng

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Chemosphere 2022 Vol.288 No.Part 1 ref.90

25. In vitro biotransformation of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate by mouse liver microsomes: kinetics and key CYP isoforms.

As the result of the phase-out on polybrominated diphenyl ethers, organophosphate flame retardants (OPFRs) were widely used as substitutes in the world. Previous studies found that OPFRs were frequently detected in environmental, biological, and human samples. Considering their adverse effects, the ...

Author(s) : Chen MeiHong; Zhang ShengHu; Jia ShiMing; Wang LiJun; Ma WanLi

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Chemosphere 2022 Vol.288 No.Part 1 ref.71