Search results: 208,330 results (approx.)

1. Active sites of peptides Asp-Asp-Asp-Tyr and Asp-Tyr-Asp-Asp protect against cellular oxidative stress.

The protective effects of the peptides Asp-Asp-Asp-Tyr (DDDY) and Asp-Tyr-Asp-Asp (DYDD) against AAPH-induced HepG2 cells are unclear. Our objective was to investigate the active sites of these peptides and their cellular antioxidant mechanism. DDDY and DYDD show a direct free radical scavenging...

Author(s) : Liu HuiFan; Liang Jiaxi; Xiao GengSheng; Vargas-De-La-Cruz, C.; Simal-Gandara, J.; Xiao JianBo; Wang Qin

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.366

2. Identification of novel antihypertensive peptides from wine lees hydrolysate.

Enzymatic-assisted extraction using Flavourzyme® has been demonstrated to be a useful methodology to obtain wine lees (WL) enriched in phenolic compounds and with enhanced antihypertensive activity. Nevertheless, taking into account that Flavourzyme® possess proteolytic activity, the release of...

Author(s) : Bravo, F. I.; Mas-Capdevila, A.; López-Fernández-Sobrino, R.; Torres-Fuentes, C.; Mulero, M.; Alcaide-Hidalgo, J. M.; Muguerza, B.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.366

3. Assessment and characterization of tomato lipophilic electrophiles and their potential contribution to nutraceutical properties via SKN-1/Nrf2 signaling activation.

Phytochemical electrophiles are drawing significant attention due to their properties to modulate signaling pathways related to cellular homeostasis. The aim of this study was to develop new tools to examine the electrophilic activity in food and predict their beneficial effects on health. We...

Author(s) : Carranza, A. del V.; Bonacci, G.; Moran, Y.; Asprelli, P.; Carrari, F.; Asis, R.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.366

4. Comparative study of the anti-obesity and gut microbiota modulation effects of green tea phenolics and their oxidation products in high-fat-induced obese mice.

Green and black teas are regarded to possess therapeutic potential for the treatment of obesity, however it is not clear which tea performs better in body weight control. In this study, aiming to eliminate cultivar variation, green tea phenolics (GTP) were oxidized by tyrosinase to obtain oxidized...

Author(s) : Liu ZhiBin; Chen Qin; Zhang Chen; Ni Li

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.367 ref.41

5. Structural elucidation and physicochemical characteristics of a novel high-molecular-weight fructan from halotolerant Bacillus sp. SCU-E108.

An exopolysaccharide, EPS-B108, was isolated from the fermented broth (with a yield of 11.3 g/L) of halotolerant Bacillus sp. SCU-E108 by ethanol precipitation, anion-exchange and gel-filtration chromatography, and well characterized by means of physical, chemical and spectral techniques. Data...

Author(s) : Gan LongZhan; Jiang GuangYang; Li XiaoGuang; Zhang ShiHao; Tian YongQiang; Peng BiYu

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2021 Vol.365

6. Preparation of S-iron-enriched yeast using siderophores and its effect on iron deficiency anemia in rats.

Efforts to obtain organic trace elements have been made, including yeast enrichment and transformation, but the application of yeast for this purpose is restricted by poor tolerance and low enrichment. Siderophores play an important role in iron transport. Thus, the role of siderophores in iron...

Author(s) : Zhang XinGuo; Wang Nan; Ma GuoDi; Liu ZiYu; Wei GuoXing; Liu WenJie

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2021 Vol.365

7. The impact of milk fat globule membrane with exercise on age-related degeneration of neuromuscular junctions.

Morphological changes in neuromuscular junctions (NMJs), which are synapses formed between α-motor neurons and skeletal muscle fibers, are considered to be important in age-related motor dysfunction. We have previously shown that the intake of dietary milk fat globule membrane (MFGM) combined with...

Author(s) : Sugita, S.; Tamura, K.; Yano, M.; Minegishi, Y.; Ota, N.

Publisher : MDPI AG, Basel, Switzerland

Journal article : Nutrients 2021 Vol.13 No.7 ref.56

8. Glucose sparing PD solution, on mesothelial cells: focus on mesothelial-mesenchymal transition, inflammation and angiogenesis.

Glucose-based solutions remain the most used osmotic agents in peritoneal dialysis (PD), but unavoidably they contribute to the loss of peritoneal filtration capacity. Here, we evaluated at a molecular level the effects of XyloCore, a new PD solution with a low glucose content, in mesothelial and...

Author(s) : Masola, V.; Bonomini, M.; Onisto, M.; Ferraro, P. M.; Arduini, A.; Gambaro, G.

Publisher : MDPI AG, Basel, Switzerland

Journal article : Nutrients 2021 Vol.13 No.7 ref.93

9. Pancreatic β cells inhibit glucagon secretion from α cells: an in vitro demonstration of α-β cell interaction.

Interactions between endocrine and cells are critical to their secretory function in vivo. The interactions are highly regulated, although yet to be fully understood. In this study, we aim to assess the impact of and cell co-culture on hormone secretion. Mouse clonal cell lines -TC6-1 (cell line)...

Author(s) : Gu, W.; Anker, C. C. B.; Christiansen, C. B.; Tilo Moede; Per-olof Berggren; Hermansen, K.; Gregersen, S.; Jeppesen, P. B.

Publisher : MDPI AG, Basel, Switzerland

Journal article : Nutrients 2021 Vol.13 No.7 ref.49

10. Undernutrition induces major alterations in the lipid droplets of white and brown adipose tissues in Wistar rats.

Several studies have shown a relationship between the distribution of fat mass around the organism, metabolic disorders, and an increased risk of morbidity and mortality. It has been demonstrated that in obese animals there is a big rise in the white fat deposits due to hyperplasia and hypertrophy...

Author(s) : Rodríguez-Rivera, C.; Santín Moreda, L.; Alguacil, L. F.; Escrivá, F.; Álvarez, C.; González-Martín, C.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Tissue & Cell 2021 Vol.71

11. Rutaecarpine ameliorated high sucrose-induced Alzheimer's disease like pathological and cognitive impairments in mice.

High sucrose can induce tau hyperphosphorylation and cognitive dysfunction/memory impairment as observed in Alzheimer's disease (AD). Rutaecarpine, a specific (transient receptor potential vanilloid 1 [TRPV1]) agonist, is neuroprotective against high sucrose diet-induced impairment, but detailed...

Author(s) : Zhao Bin; Wang Yi; Liu Rui; Jia XiaoLi; Hu Nan; An XingWei; Zheng ChenGuang; Chen Chong; Sun HongTao; Chen Feng; Wang JingJing; Li XiaoHong

Publisher : Mary Ann Liebert, Inc., New Rochelle, USA

Journal article : Rejuvenation Research 2021 Vol.24 No.3 pp.181-190

12. Fermented milk modulates immune systemic response and intestinal epithelial structure in Balb/c mice sensitized to bovine whey proteins.

In epidemiological studies, cow's milk protein allergy (CMPA) is the most prevalent allergy for infants or young children. This study was conducted to compare the effect of Soummam and Saifi fermented milks on mice sensiti-zed to whey protein (β -Lactoglobulin and α -Lactalbumin). During 28 days,...

Author(s) : Yamina, B.; Samia, A.; Wafaa, D.; Hafsia, A.; Mama, B.; Djamel, S.; Omar, K.

Publisher : Infofacility, Ghaziabad, India

Journal article : South Asian Journal of Experimental Biology 2021 Vol.11 No.4 pp.400-406 ref.25

13. Kaempferol attenuates diquat-induced oxidative damage and apoptosis in intestinal porcine epithelial cells.

Kaempferol, a flavonol component of plants, is well-known to exhibit multiple bioactivities, such as anti-oxidative and anti-apoptotic effects. However, the underlying mechanisms responsible for the beneficial effects remain elusive. This study was conducted to test the hypothesis that kaempferol...

Author(s) : Jin YuHang; Zhai ZhiAn; Jia Hai; Lai JinHua; Si XueMeng; Wu ZhenLong

Publisher : Royal Society of Chemistry, Cambridge, UK

Journal article : Food and Function 2021 Vol.12 No.15 pp.6889-6899

14. Polysaccharide from Ganoderma lucidum ameliorates cognitive impairment by regulating the inflammation of the brain-liver axis in rats.

Ganoderma lucidum (G. lucidum) polysaccharide-1 (GLP-1) is one of the polysaccharides isolated from the fruiting bodies of G. lucidum. Inflammation in the brain-liver axis plays a vital role in the progress of cognitive impairment. In this study, the beneficial effect of GLP-1 on D-galactose...

Author(s) : Zhang Yan; Li HaiTao; Song LianLian; Xue JianFei; Wang XinYan; Song Shuang; Wang Shuang

Publisher : Royal Society of Chemistry, Cambridge, UK

Journal article : Food and Function 2021 Vol.12 No.15 pp.6900-6914

15. Blockage of Fc gamma receptors alleviates neuronal and microglial toxicity induced by palmitic acid.

Background: Palmitic acid (PA) promotes brain pathologies including Alzheimer's disease (AD)-related proteins, neuroinflammation, and microglial activation. The activation of neurons and microglia via their Fc gamma receptors (FcγRs) results in producing inflammatory cytokines. Objective: To...

Author(s) : Phitthayaphong, P.; Kumfu, S.; Chattipakorn, N.; Chattipakorn, S.

Publisher : IOS Press, Amsterdam, Netherlands

Journal article : JAD, Journal of Alzheimer's Disease 2021 Vol.82 No.3 pp.1315-1332

16. Butylated hydroxyanisole: carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply?

Tumor data from rodent bioassays are used for cancer hazard classification with wide-ranging consequences. This paper presents a case study of the synthetic antioxidant butylated hydroxyanisole (BHA), which IARC classified as Group 2B ("possibly carcinogenic to humans") on the basis of forestomach...

Author(s) : Felter, S. P.; Zhang XiaoLing; Thompson, C.

Publisher : Elsevier, New York, USA

Journal article : Regulatory Toxicology and Pharmacology 2021 Vol.121 ref.many

17. Reproductive and developmental toxicity screening study of an acetone extract of rosemary.

In 2017, JECFA requested reproductive and developmental toxicity studies to finalize an acceptable daily intake for solvent rosemary extracts. Thus, an OECD 421 reproductive/developmental toxicity study was conducted using an acetone rosemary extract that complied with JECFA and EFSA food additive...

Author(s) : Phipps, K. R.; Danielewska-Nikiel, B.; Mushonganono, J.; Baldwin, N.

Publisher : Elsevier, New York, USA

Journal article : Regulatory Toxicology and Pharmacology 2021 Vol.120

18. The effect of Electron beam on oxidative stress and inflammatory factors in diabetes mellitus: an in vitro and in vivo study.

Background: The main purpose of this study was to investigate whether or not electron beam therapy (EBT) was an effective method in terms of moderating oxidative stress by reducing free radicals in BALB/c mice with type 1 diabetes mellitus. Methods: The study was performed on thirty BALB/c mice in...

Author(s) : Martirosyan, D.; Shahnazari-Aval, M.; Ashoori, M. R.; Mikaeili, A. S.; Nakhjavani, M.; Mirmiranpour, H.

Publisher : Food Science Publisher, Denton, USA

Journal article : Functional Foods in Health and Disease 2021 Vol.11 No.7 pp.333-344 ref.49

19. Toxic mechanism of pyrene to catalase and protective effects of vitamin C: studies at the molecular and cell levels.

Polycyclic aromatic hydrocarbons, distributing extensively in the soil, would potentially threaten the soil organisms (Eisenia fetida) by triggering oxidative stress. As a ubiquitous antioxidant enzyme, catalase can protect organisms from oxidative damage. To reveal the potential impact of...

Author(s) : Sun Ning; Li MeiFei; Liu GuiLiang; Jing MingYang; He FaLin; Cao ZhaoZhen; Zong WanSong; Tang JingChun; Gao CanZhu; Liu RuTao

Publisher : Elsevier Ltd, Oxford, UK

Journal article : International Journal of Biological Macromolecules 2021 Vol.171 pp.225-233

20. Selenium-deficient diet induces inflammatory response in the pig adrenal glands by activating TLR4/NF-κB pathway via miR-30d-R_1.

Selenium (Se) is an important trace element to maintain the body's dynamic balance. Lack of Se can cause inflammation. Studies have shown that inflammation often leads to disorders of the hypothalamic-pituitary-adrenal axis, but the mechanism by which Se deficiency causes inflammation of the...

Author(s) : Zhang KaiXin; Gu XueDie; Lan Jing; Zhang YiMing; Pervez, A. K.; Liu ZhaoYi; Li Shu

Publisher : Oxford University Press, Oxford, UK

Journal article : Metallomics 2021 Vol.13 No.7

21. Carnosine improves aging-induced cognitive impairment and brain regional neurodegeneration in relation to the neuropathological alterations in the secondary structure of amyloid beta (Aβ).

Aging-induced proteinopathies, including deterioration of amyloid beta (Aβ) conformation, are associated with reductions in endogenous levels of carnosine and cognitive impairments. Carnosine is a well-known endogenous antioxidant, which counteracts aging-induced Aβ plaque formation. The aim of...

Author(s) : Soumyabrata Banerjee; Biswajit Mukherjee; Poddar, M. K.; Dunbar, G. L.

Publisher : Wiley, Oxford, UK

Journal article : Journal of Neurochemistry 2021 Vol.158 No.3 pp.710-723

22. Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.

Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants mechanistically affect whole-body physiology. We engineered a deletion of the rs1421085 conserved cis-regulatory module (CRM) in mice and confirmed in vivo that the CRM modulates ...

Author(s) : Laber, S.; Forcisi, S.; Bentley, L.; Petzold, J.; Moritz, F.; Smirnov, K. S.; Al-Sadat, L.; Williamson, I.; Strobel, S.; Agnew, T.; Sengupta, S.; Nicol, T.; Grallert, H.; Heier, M.; Honecker, J.; Mianne, J.; Teboul, L.; Dumbell, R.; Long, H.; Simon, M.; Lindgren, C.; Bickmore, W. A.; Hauner, H.; Schmitt-Kopplin, P.; Claussnitzer, M.; Cox, R. D.

Publisher : American Association for the Advancement of Science, Washington, USA

Journal article : Science Advances 2021 Vol.7 No.30 ref.79

23. Vitamin D3 attenuates doxorubicin-induced senescence of human aortic endothelial cells by upregulation of IL-10 via the pAMPKα/Sirt1/Foxo3a signaling pathway.

The toxicity of doxorubicin to the cardiovascular system often limits its benefits and widespread use as chemotherapy. The mechanisms involved in doxorubicin-induced cardiovascular damage and possible protective interventions are not well-explored. Using human aortic endothelial cells, we show...

Author(s) : Chen Lei; Holder, R.; Porter, C.; Shah, Z.

Publisher : Public Library of Sciences (PLoS), San Francisco, USA

Journal article : PLoS ONE 2021 Vol.16 No.6 ref.42

24. Impact of ellagic acid application on doxorubicin-induced cardiovascular toxicity model.

Doxorubicin is an anticancer agent that is commonly used to treat a number of tumors and is associated with acute and chronic changes of the cardiovascular system. Ellagic acid has strong free radical scavenging capacity, neuroprotective and hepatoprotective effects, and is known to protect against ...

Author(s) : Salinger-Martinovic, S.; Cosic, V.; Stojiljkovic, N.; Ilic, S.; Stojanovic, N.; Dencic, T.

Publisher : NRC Research Press, Ottawa, Canada

Journal article; Conference paper : Canadian Journal of Physiology and Pharmacology 2021 Vol.99 No.2 pp.185-191 ref.27

25. Licorice flavonoid oil supplementation promotes a reduction of visceral fat in exercised rats.

BACKGROUND: The beneficial effect of exercise combined with licorice flavonoid oil supplementation on visceral fat was investigated. METHODS: Male Sprague-Dawley rats were divided into 4 groups: control, exercise (Ex), control with licorice flavonoid oil supplementation (LFO), and exercise with...

Author(s) : Tanaka, M.; Kanazashi, M.; Kondo, H.; Ishihara, A.; Fujino, H.

Publisher : Edizioni Minerva Medica, Torino, Italy

Journal article : Journal of Sports Medicine and Physical Fitness 2021 Vol.61 No.3 pp.480-488