Search results: 37,730 results (approx.)

1. Dynamical network biomarkers: theory and applications.

This paper reviews theory of DNB (Dynamical Network Biomarkers) and its applications including both modern medicine and traditional medicine. We show that omics data such as gene/protein expression profiles can be effectively used to detect pre-disease states before critical transitions from...

Author(s) : Aihara, K.; Liu Rui; Koizumi, K.; Liu XiaoPing; Chen LuoNan

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Gene 2022 Vol.808 ref.47

2. A turn-on fluorescence sensor based on Cu2+ modulated DNA-templated silver nanoclusters for glyphosate detection and mechanism investigation.

The abuse application of glyphosate can result in a potential hazard for environment and human, however its ultrasensitive detection remains challenging. Herein, a Cu2+ modulated DNA-templated silver nanoclusters (DNA-AgNCs) sensor was constructed to sensitively determine glyphosate based on the...

Author(s) : Yang YiXia; Ghalandari, B.; Lin LiYun; Sang Xiao; Su WenQiong; Divsalar, A.; Ding XianTing

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.367 ref.42

3. Eating disinhibition and food liking are influenced by variants in CAV1 (caveolin 1) gene.

Eating behavior is influenced by a combination of environmental and genetic factors. Although candidate gene studies have been conducted, much remains to be understood about genetic influences. Therefore, we conducted a Genome-Wide Association Study (GWAS) aims to identify new variants that...

Author(s) : Concas, M. P.; Cocca, M.; Catamo, E.; Gasparini, P.; Robino, A.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Quality and Preference 2022 Vol.96 ref.64

4. Dietary omega-3 fatty acid intake impacts peripheral blood DNA methylation -anti-inflammatory effects and individual variability in a pilot study.

Omega-3 or n-3 polyunsaturated fatty acids (PUFAs) are widely studied for health benefits that may relate to anti-inflammatory activity. However, mechanisms mediating an anti-inflammatory response to n-3 PUFA intake are not fully understood. Of interest is the emerging role of fatty acids to impact ...

Author(s) : Frankhouser, D. E.; Steck, S.; Sovic, M. G.; Belury, M. A.; Wang, Q.; Clinton, S. K.; Bundschuh, R.; Yan, P. S.; Yee, L. D.

Publisher : Elsevier, New York, USA

Journal article : Journal of Nutritional Biochemistry 2022 Vol.99 ref.67

5. The association between serum level and genetic variation of IL-3 (rs40401) in recurrent abortion women infected with toxoplasmosis in Iraq.

Toxoplasmosis is one of the most infections during pregnancy transmitted from mother to child via the placenta and causes morbidity and mortality prenatally. IL-3 is a hematopoiesis enhancing factor and assist in the implantation embryo and placental growth. The objective of this study is to...

Author(s) : Noor, N. B.; Ahmed, N. S.; Saheb, E. J.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Cytokine 2022 Vol.149 ref.21

6. Association of HLA-DRB1 and -DQB1 alleles with susceptibility to IgA nephropathy in Korean patients.

Background: Associations between IgA nephropathy (IgAN) and HLA-DRB1 and -DQB1 alleles have been reported in several ethnic groups. We investigated the association of HLA-DRB1 and -DQB1 alleles with the predisposition for IgAN and disease progression to end-stage kidney disease (ESKD) in Korean...

Author(s) : In JiWon; Jung Kiwook; Shin Sue; Park KyoungUn; Lee Hajeong; Song EunYoung

Publisher : Korean Society for Laboratory Medicine, Seoul, Korea Republic

Journal article : Annals of Laboratory Medicine 2022 Vol.42 No.1 pp.54-62 ref.40

7. Clinical utility of methylation-specific multiplex ligation-dependent probe amplification for the diagnosis of Prader-Willi syndrome and Angelman syndrome.

Background: Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are genomic imprinting disorders that are mainly caused by a deletion on 15q11-q13, the uniparental disomy of chromosome 15, or an imprinting defect. We evaluated the utility of methylation-specific multiplex ligation-dependent...

Author(s) : Kim Boram; Park Yongsook; Cho SungIm; Kim ManJin; Seong MoonWoo; Park SungSup; Kim JiYeon; Chae JongHee

Publisher : Korean Society for Laboratory Medicine, Seoul, Korea Republic

Journal article : Annals of Laboratory Medicine 2022 Vol.42 No.1 pp.79-88 ref.28

8. Association of allelic combinations in selenoprotein and redox related genes with markers of lipid metabolism and oxidative stress - multimarkers analysis in a cross-sectional study.

Background: Selenium (Se) and selenoproteins have been shown to be involved in lipid metabolism mainly due to their ability to modulate redox homeostasis in adipose tissue. The underlying mechanisms are yet to be evaluated. In the light of few data related to the association between polymorphic...

Author(s) : Tarhonska, K.; Raimondi, S.; Specchia, C.; Wieczorek, E.; Reszka, E.; Krol, M. B.; Gromadzinska, J.; Wasowicz, W.; Socha, K.; Borawska, M. H.; Jablonska, E.

Publisher : Elsevier GmbH, Munich, Germany

Journal article : Journal of Trace Elements in Medicine and Biology 2022 Vol.69 ref.48

9. The interaction between genetic polymorphisms in FTO, MC4R and MTHFR genes and adherence to the Mediterranean diet in relation to obesity.

Aims: To investigate the potential interaction between genetic background and adherence to the Mediterranean Diet, macronutrient intake and physical activity with regard to obesity in a sample of healthy adults. Design: Cross-sectional epidemiological study including 392 adults living in the...

Author(s) : Aoun, C.; Hajj, A.; Hajj, F.; Papazian, T.; Khabbaz, L. R.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Gene 2022 Vol.809 ref.59

10. Integrating SNPs-based genetic risk factor with blood epigenomic response of differentially arsenic-exposed rural subjects reveals disease-associated signaling pathways.

Arsenic (As) contamination in groundwater is responsible for numerous adverse health outcomes among millions of people. Epigenetic alterations are among the most widely studied mechanisms of As toxicity. To understand how As exposure alters gene expression through epigenetic modifications, a...

Author(s) : Rehman, M. Y. A.; Briedé, J. J.; Herwijnen, M. van; Krauskopf, J.; Jennen, D. G. J.; Malik, R. N.; Kleinjans, J. C. S.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Environmental Pollution 2022 Vol.292 No.Part A ref.142

11. Detection methods and status of CAT interruption of ATXN1 in Korean patients with spinocerebellar ataxia type 1.

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant disease caused by abnormal CAG repeat expansion in the ataxin 1 gene (ATXN1). The presence of CAT interruption(s) is important for diagnosing SCA1 in patients with 39-44 repeat alleles, as only uninterrupted alleles are considered...

Author(s) : Jang JaHyun; Yoon SunJoo; Kim SunKyung; Cho JinWhan; Kim JongWon

Publisher : Korean Society for Laboratory Medicine, Seoul, Korea Republic

Journal article : Annals of Laboratory Medicine 2022 Vol.42 No.2 pp.274-277 ref.17

12. Pro-inflammatory and anti-inflamatory cytokine genes polymorphisms and susceptibility to Japanese encephalitis disease in the North Indian population.

Background: Japanese encephalitis virus (JEV) is the major cause of viral encephalitis in many regions of Asia. Cytokines, including pro-inflammatory and anti-inflammatory are key regulators playing a detrimental role in the host response to JE infection, pathogenesis and disease outcome....

Author(s) : Sneha Ghildiyal; Tanzeem Fatima; Dharamveer Singh; Shivbrat Upadhyay; Dhole, T. N.; Reddy, D. H.; Alok Kumar

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Cytokine 2022 Vol.149 ref.38

14. Why women may live longer than men do? A telomere-length regulated and diet-based entropic assessment.

Background & aims: Empirical analyses of the data available around the word concluded that women have longer life span now, when compared to the men. Available literature unfortunately could not offer full answers to this observation. The "entropic age" concept suggests that ageing related...

Author(s) : Öngel, M. E.; Yildiz, C.; Akpinaroglu, C.; Yilmaz, B.; Özilgen, M.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Clinical Nutrition 2021 Vol.40 No.3 pp.1186-1191

15. Higher tea consumption is associated with decreased risk of small vessel stroke.

Background & aim: Observational studies have reported that tea consumption is associated with risk of stroke. However, this observed association is inconsistent, and whether this observed association is due to confounding factors or reverse causation remains unclear. Thus, we applied a...

Author(s) : Wang MengMeng; Bai YongJie; Wang Zhen; Zhang ZhiZhong; Liu DanDan; Lian XueGan

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Clinical Nutrition 2021 Vol.40 No.3 pp.1430-1435

16. Predicting anthropometric and metabolic traits with a genetic risk score for obesity in a sample of Pakistanis.

Obesity is an outcome of multiple factors including environmental and genetic influences. Common obesity is a polygenic trait indicating that multiple genetic variants act synergistically to influence its expression. We constructed a genetic risk score (GRS) based on five genetic variants (MC4R...

Author(s) : Rana, S.; Bhatti, A. A.

Publisher : Nature Publishing Group, London, UK

Journal article : Scientific Reports 2021 Vol.11 No.4 ref.61

17. Influence of the bioactive diet components on the gene expression regulation.

Diet bioactive components, in the concept of nutrigenetics and nutrigenomics, consist of food constituents, which can transfer information from the external environment and influence gene expression in the cell and thus the function of the whole organism. It is crucial to regard food not only as...

Author(s) : Mierziak, J.; Kostyn, K.; Boba, A.; Czemplik, M.; Kulma, A.; Wojtasik, W.

Publisher : MDPI AG, Basel, Switzerland

Journal article : Nutrients 2021 Vol.13 No.11 ref.370

18. Examination of the predicted prevalence of Gitelman syndrome by ethnicity based on genome databases.

Gitelman syndrome is an autosomal recessive inherited salt-losing tubulopathy. It has a prevalence of around 1 in 40,000 people, and heterozygous carriers are estimated at approximately 1%, although the exact prevalence is unknown. We estimated the predicted prevalence of Gitelman syndrome based on ...

Author(s) : Kondo, A.; Nagano, C.; Ishiko, S.; Omori, T.; Aoto, Y.; Rossanti, R.; Sakakibara, N.; Horinouchi, T.; Yamamura, T.; Nagai, S.; Okada, E.; Shima, Y.; Nakanishi, K.; Ninchoji, T.; Kaito, H.; Takeda, H.; Nagase, H.; Morisada, N.; Iijima, K.

Publisher : Nature Publishing Group, London, UK

Journal article : Scientific Reports 2021 Vol.11 No.8 ref.21

19. Regulatory and intellectual property conundrums surrounding xenotransplantation.

Author(s) : Kwisda, K.; Cantz, T.; Hoppe, N.

Publisher : Nature Publishing Group, New York, USA

Journal article : Nature Biotechnology 2021 Vol.39 No.7 pp.796-798 ref.23

20. Integration of summary data from GWAS and eQTL studies identified novel risk genes for coronary artery disease.

Several genetic loci have been reported to be significantly associated with coronary artery disease (CAD) by multiple genome-wide association studies (GWAS). Nevertheless, the biological and functional effects of these genetic variants on CAD remain largely equivocal. In the current study, we...

Author(s) : Zhong YiGang; Chen LiuYing; Li JingJing; Yao YingHao; Liu Qiang; Niu KaiMeng; Ma YunLong; Xu YiZhou

Publisher : Lippincott Williams & Wilkins, Inc., Hagerstown, USA

Journal article : Medicine (Baltimore) 2021 Vol.100 No.11 ref.77

21. Association between SLCO1B1 polymorphism distribution frequency and blood lipid level in Chinese adults.

Background: The variation of serum lipid levels can be part-related to certain genes. One such gene, SLCO1B1, encodes a transporter that may have a role in lipid metabolism. We hypothesised that differences in certain SLCO1B1 genotypes are related to levels of serum lipids. Materials and methods:...

Author(s) : Mo, Q.; Huang, S.; Ma, J.; Zhang, J.; Su, R.; Deng, Q.

Publisher : Taylor & Francis, Abingdon, UK

Journal article : British Journal of Biomedical Science 2021 Vol.78 No.1 pp.23-27 ref.28

22. Barth syndrome: cardiolipin, cellular pathophysiology, management, and novel therapeutic targets.

Barth syndrome is a rare X-linked genetic disease classically characterized by cardiomyopathy, skeletal myopathy, growth retardation, neutropenia, and 3-methylglutaconic aciduria. It is caused by mutations in the tafazzin gene localized to chromosome Xq28.12. Mutations in tafazzin may result in...

Author(s) : Zegallai, H. M.; Hatch, G. M.

Publisher : Springer, New York, USA

Journal article : Molecular and Cellular Biochemistry 2021 Vol.476 No.3 pp.1605-1629 ref.194

23. MiR-22-3p suppresses adipocyte formation of telomerase transformed mesenchymal stromal cells (iMSC3) by regulating non-targeted MAPK signaling pathway.

Unraveling molecular mechanisms that govern adipocyte formation will lead to a greater understanding of obesity and subsequent treatment. In the current study, we assessed the effects of miR-22-3p, a non-coding RNA, on adipocyte differentiation from telomerase-transformed Mesenchymal Stromal Cells...

Author(s) : Alomran, S. S.; Khattak, M. N. K.; Khan, A. A.; Abdallah, S. H.; Fayyad, A. M.; Bajou, K.

Publisher : Zoological Society of Pakistan, Lahore, Pakistan

Journal article : Pakistan Journal of Zoology 2021 Vol.53 No.4 pp.1491-1499 ref.27

24. Acute myocardial infarction in a 41-year-old woman due to elevated factor viii.

Myocardial infarction is a life-threatening emergency with a high mortality rate. A high plasma level of factor VIII is an established risk for both arterial and venous thrombotic events. In this mini-review, we report the case of a 41-year-old woman without cardiovascular risk factors or a...

Author(s) : Brem, F. L.; Rasras, H.; El-Ouafi, N.; Bazid, Z.

Publisher : African Field Epidemiology Network, Kampala, Uganda

Journal article : Pan African Medical Journal 2021 Vol.38 ref.16