Search results: 26,183 results (approx.)

1. Novel synthesis of fluorescent carbon dots from bio-based Carica Papaya leaves: optical and structural properties with antioxidant and anti-inflammatory activities.

Fluorescent carbon dots (CDs) are prepared from a natural resource Carica Papaya Leaves, by sand bath method. The as-synthesized CDs optical and structural properties were characterized by UltraViolet-Visible, FT- IR, and fluorescence spectroscopy. Also the size, shape, and particle size...

Author(s) : Gudimella, K. K.; Gangaraju Gedda; Kumar, P. S.; Babu, B. K.; Bhaskar Yamajala; Rao, B. V.; Singh, P. P.; Deepak Kumar; Ajit Sharma

Publisher : Elsevier Inc, Orlando, USA

Journal article : Environmental Research 2022 Vol.204 No.Part A ref.40

2. Construction and activity evaluation of novel benzodioxane derivatives as dual-target antifungal inhibitors.

Ergosterol exert the important function in maintaining the fluidity and osmotic pressure of fungal cells, and its key biosynthesis enzymes (Squalene epoxidase, SE; 14 α-demethylase, CYP51) displayed the obvious synergistic effects. Therefore, we expected to discover the novel antifungal compounds...

Author(s) : An YunFei; Liu WenXia; Xie HongLei; Fan HaiYan; Han Jun; Sun Bin

Publisher : Elsevier Masson SAS, Issy-les-Moulineaux, France

Journal article : European Journal of Medicinal Chemistry 2022 Vol.227 ref.34

3. Special Issue: Natural products research and application: promoting the research level on natural products and propelling the development of public health industry.

This special issue contains 10 papers focusing on the latest developments in chemistry, pharmacy, biochemistry and molecular biology related to natural product research.

Publisher : Science Press, Beijing, China

Journal issue : Chinese Journal of Applied Chemistry 2021 Vol.38 No.3 pp.245-342

4. Green synthesis of walnut shell hydrochar, its antimicrobial activity and mechanism on some pathogens as a natural sanitizer.

Hydrochar of waste walnut shells (WSH) was synthesized in the eco-friendly subcritical water medium (SWM) and its potential to fight against Klebsiella pneumoniae (K. pneumoniae), Staphylococcus aureus (S. aureus), Candida albicans (C. albicans) and Candida parapsilosis (C. parapsilosis) was...

Author(s) : Yabalak, E.; Erdogan Eliuz, E. A.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Chemistry 2022 Vol.366

5. Acacia auriculiformis pericarp - a substitute of Mohua oil cake as piscicide in pre-stocking pond preparation.

Mahua oil cake (MOC), a derivative of the seeds from Bassia latifolia is used as a piscicide in pre-stocking pond preparation for composite fish culture. However, for its nutritional potency MOC is used as a protein substitute in the formulated diets for fish, poultry and cattle. In present...

Author(s) : Beauty Saha; Saha, S. K.

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Aquaculture 2022 Vol.548 No.Part 1 ref.47

6. Discovery and optimization of new 6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline derivatives as potent influenza virus PAN inhibitors.

Annual unpredictable efficacy of vaccines, coupled with emerging drug resistance, underlines the development of new antiviral drugs to treat influenza infections. The N-terminal domain of the PA (PAN) endonuclease is both highly conserved across influenza strains and serotypes and is indispensable...

Author(s) : Liu ZhiHao; Gu ShuYin; Zhu Xiang; Liu MingJian; Cao ZhenQing; Qiu PengSen; Li SuMei; Liu ShuWen; Song GaoPeng

Publisher : Elsevier Masson SAS, Issy-les-Moulineaux, France

Journal article : European Journal of Medicinal Chemistry 2022 Vol.227 ref.39

7. Design, synthesis and biological evaluation of novel evodiamine and rutaecarpine derivatives against phytopathogenic fungi.

Evodiamine and rutaecarpine are two alkaloids isolated from traditional Chinese herbal medicine Evodia rutaecarpa, which have been reported to have various biological activities in past decades. To explore the potential applications for evodiamine and rutaecarpine alkaloids and their derivatives,...

Author(s) : Yang ChengJie; Li HaiXin; Wang JingRu; Zhang ZhiJun; Wu TianLin; Liu YingQian; Tang Chen; Chu QingRu; Du ShaSha; He YingHui

Publisher : Elsevier Masson SAS, Issy-les-Moulineaux, France

Journal article : European Journal of Medicinal Chemistry 2022 Vol.227

8. Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents.

5-phenylthiophene derivatives exhibited excellent antifungal activity against Candida albicans, Candida tropicalis and Cryptococcus neoformans. However, optimal compound 7 was inactive against Aspergillus fumigatus and unstable in human liver microsomes in vitro with a half-life of 18.6 min. To...

Author(s) : Yin WenBo; Cui HengXian; Jiang Hong; Zhang YuXin; Liu Lei; Wu TianXiao; Sun Yin; Zhao LiYu; Su Xin; Zhao DongMei; Cheng MaoSheng

Publisher : Elsevier Masson SAS, Issy-les-Moulineaux, France

Journal article : European Journal of Medicinal Chemistry 2022 Vol.227 ref.29

9. Prediction of potential cysteine synthase inhibitors of Leishmania braziliensis and Leishmania major parasites by computational screening.

Leishmaniasis is a neglected tropical disease considered a public health problem that requires innovative strategies for its chemotherapeutic control. In the present investigation, a molecular docking approach was carried out using the protein cysteine synthase (CS) of Leishmania braziliensis...

Author(s) : Téllez, J.; Amarillo, A.; Suarez, C.; Cardozo, C.; Guerra, D.; Ochoa, R.; Muskus, C.; Romero, I.

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Acta Tropica 2022 Vol.225 ref.65

10. Synthesis and biological profiling of half-calycanthaceous alkaloid analogues.

During our continuous efforts to pursue antifungal agents, some calycanthaceous alkaloid analogs showed diverse and promising bioactivities. Therefore, 34 new calycanthaceous alkaloid derivatives were further prepared and screened for bioactivities. As a result of the evaluation against a great...

Author(s) : Zhu Rui; Wei Yang; Han Ke; Shi XinWei; Gu YongDong; Bai HongJin; Zheng ShaoJun

Publisher : Taylor & Francis, Abingdon, UK

Journal article : Journal of Asian Natural Products Research 2021 Vol.23 No.9 pp.859-865 ref.25

11. Structural characterization of the pawl-derived peptide family, an ancient subfamily of orbitides.

Plants are an excellent source of bioactive peptides, often with disulfide bonds and/or a cyclic backbone. While focus has predominantly been directed at disulfide-rich peptides, a large family of small, cyclic plant peptides lacking disulfide bonds, known as orbitides, has been relatively ignored. ...

Author(s) : Payne, C. D.; Fisher, M. F.; Mylne, J. S.; Rosengren, K. J.

Publisher : American Chemical Society, Washington, USA

Journal article : Journal of Natural Products 2021 Vol.84 No.11 pp.2914-2922 ref.49

12. Hydrohydroxymethylation of ethyl ricinoleate and Castor oil.

The direct functionalization of the carbon-carbon double bonds of castor oil and its derivatives is of major interest to access biosourced building blocks. In particular, polyol derivatives can be produced in this way and find application in the field of bio-based polyesters and polyurethanes. In...

Author(s) : Becquet, C.; Berche, F.; Bricout, H.; Monflier, E.; Tilloy, S.

Publisher : American Chemical Society, Washington, USA

Journal article : ACS Sustainable Chemistry & Engineering 2021 Vol.9 No.28 pp.9444-9454

13. Quantification of atovaquone from amorphous solid dispersion formulation using HPLC: an in vitro and ex vivo investigation.

Atovaquone (ATQ) is a poorly soluble drug. Therefore, formulating ATQ into its supersaturated state through solid dispersion for bioavailability enhancement can be of great value. However, due to fast crystallising properties of ATQ, the quantification of ATQ in a supersaturated solid dispersion...

Author(s) : Teoh XinYi; Goh ChoonFu; Nafiu Aminu; Chan SiokYee

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Journal of Pharmaceutical and Biomedical Analysis 2021 Vol.192 ref.30

14. Fabrication of poly-sulfosalicylic acid film decorated pure carbon fiber as electrochemical sensing platform for detection of theophylline.

In this work, we integrated the superiority of good conductivity, large surface area of carbon fibers and the catalytic property, good biocompatibility of polymer sulfosalicylic acid to construct a novel electrochemical sensor to detect theophylline in drug analysis. The morphology of nanocomposite ...

Author(s) : Duan YingChun; Wang AnQing; Ding YaPing; Li Li; Duan DingDing; Lin JiaXin; Yu ChenHong; Liu Jiayifan

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Journal of Pharmaceutical and Biomedical Analysis 2021 Vol.192

15. Polysaccharide-based chiral stationary phases as efficient tools for diastereo- and enantioseparation of natural and synthetic Cinchona alkaloid analogs.

In this study, we present results obtained on the diastereo- and enantioseparation of some basic natural and synthetic Cinchona alkaloid analogs by applying liquid chromatographic (LC) and subcritical fluid chromatographic (SFC) modalities on amylose and cellulose tris-(phenylcarbamate)-based...

Author(s) : Bajtai, A.; Ilisz, I.; Berkecz, R.; Fülöp, F.; Lindner, W.; Péter, A.

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Journal of Pharmaceutical and Biomedical Analysis 2021 Vol.193 ref.35

16. Application of electrospinning technology of natural products in biomedicine.

Electrospinning nanofibers have become a hot topic in many fields, such as energy and environment, health care, food packaging, nano equipment development and so on, especially in biomedical fields such as drug transportation, wound care and tissue engineering, because of its large specific surface ...

Author(s) : Cheng CuiLin; Ma JiaPei; Wang WeiChen; Wang BoYang; Wang ZhenYu

Publisher : Science Press, Beijing, China

Journal article : Chinese Journal of Applied Chemistry 2021 Vol.38 No.6 pp.605-614

17. Synthesis, fungicidal activity, and 3D-QSAR of tetrazole derivatives containing phenyloxadiazole moieties.

In an effort to discover new agents with good fungicidal activities against CDM (cucumber downy mildew), a series of tetrazole derivatives containing phenyloxadiazole moieties were designed and synthesized. The EC50 values for fungicidal activities against CDM were determined. Bioassay results...

Author(s) : Li YiTao; Yao WenQiang; Zhou Si; Xu JunXing; Lu Hui; Lin Jian; Hu XiaoYun; Zhang ShaoKai

Publisher : Elsevier, Cambridge, UK

Journal article : Bioorganic & Medicinal Chemistry Letters 2021 Vol.34

18. New drugs for small animals in 2020.

In 2020, one novel pharmaceutical agent for small animals, the ACTH analog tetracosactide for the assessment of adrenocortical function in dogs, were released on the German market. Two established veterinary active pharmaceutical ingredients became available for additional species: The dissociative ...

Foreign Title :Neue Arzneimittel für Kleintiere 2020.

Author(s) : Emmerich, I. U.

Publisher : Georg Thieme Verlag KG, Stuttgart, Germany

Journal article : Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere 2021 Vol.49 No.2 pp.129-133 ref.11

19. Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the ayurvedic traditional medicine "Salacia", against human intestinal maltase.

Four chain-extended analogs (12a-12d) and two related de-O-sulfonated analogs (13a and 13c) by introducing alkyl groups (a: R = C3H7, b R = C6H13, c: R = C8H17, d: R = C10H21) to the side chains of salacinol (1), a natural α-glucosidase inhibitor from Ayurvedic traditional medicine "Salacia", were...

Author(s) : Takashima, K.; Sakano, M.; Kinouchi, E.; Nakamura, S.; Marumoto, S.; Ishikawa, F.; Ninomiya, K.; Nakanishi, I.; Morikawa, T.; Tanabe, G.

Publisher : Elsevier, Cambridge, UK

Journal article : Bioorganic & Medicinal Chemistry Letters 2021 Vol.33

20. Discovery of novel iminosydnone compounds with insecticidal activities based on the binding mode of triflumezopyrim.

Triflumezopyrim (TFM) is a new mesoionic insecticide developed by DuPont. Like other neonicotinoid insecticides, it binds to the orthosteric site of the nicotinic acetylcholine receptor (nAChR), but the binding mode has not been reported. Nicotinic acetylcholine binding proteins (nAChBPs) are ideal ...

Author(s) : Du ShaoQing; Hu XuePing; Li MengNan; Jiang XiaoQun; Xu XiaoYong; Cheng JiaGao; Qian XuHong

Publisher : Elsevier, Cambridge, UK

Journal article : Bioorganic & Medicinal Chemistry Letters 2021 Vol.46

21. Antimalarial activity of 2,6-dibenzylidenecyclohexanone derivatives.

Malaria remains one of the deadliest infectious diseases worldwide and continues to infect hundreds of millions of individuals each year. Here we report the discovery and derivatization of a series of 2,6-dibenzylidenecyclohexanones targeting the chloroquine-sensitive 3D7 strain of Plasmodium...

Author(s) : Eagon, S.; Hammill, J. T.; Fitzsimmons, K.; Sienko, N.; Nguyen, B.; Law, J.; Manjunath, A.; Wilkinson, S. P.; Thompson, K.; Glidden, J. E.; Rice, A. L.; Falade, M. O.; Kimball, J. J.; Dibernardo, C.; Guy, R. K.

Publisher : Elsevier, Cambridge, UK

Journal article : Bioorganic & Medicinal Chemistry Letters 2021 Vol.47 ref.11

22. Synthesis and fungicidal activity of novel 2-(2-alkylthio-6-phenylpyrimidin-4-yl)-1H-benzimidazoles.

With the aim of exploring new benzimidazole derivative with high fungicidal activity, a series of novel 2-(2-(alkylthio)-6-phenylpyrimidin-4-yl)-1H-benzimidazoles were designed and synthesized, and their in vitro fungicidal activities were evaluated. Compounds 5a, 5f, 5g, 5h, 5i and 5l exhibited...

Author(s) : Sun ChangXing; Zhang Shuai; Qian Ping; Li Ying; Deng Hao; Ren WanSheng; Jiang Lin

Publisher : Elsevier, Cambridge, UK

Journal article : Bioorganic & Medicinal Chemistry Letters 2021 Vol.47

23. Facile synthesis of an aggregation-induced emission (AIE) active imidazoles for sensitive detection of trifluralin.

A novel imidazoles fluorescent probe (2) was synthesized from vanillin, o-phenylenediamine, and N,N-diphenylcarbamyl chloride. Its structure was characterized by fluorescence spectra, UV-Vis spectra, 1H NMR, 13C NMR, and high-resolution mass spectrometry (HRMS). Moreover, its aggregation-induced...

Author(s) : Wang JunJie; Xia TianZi; Lan ZhenNi; Liu GuangYan; Hou ShiLi; Hou ShiFeng

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2021 Vol.259

24. Optimisation of alginate-pectin bead formulation using central composite design guided electrospray technique.

Alginate-pectin beads act as a carrier in improving the oral bioavailability of bioactive compounds. Electrospray technique facilitates the production of uniform size and shape of alginate-pectin beads. Interaction between key electrospray process parameters affects the size and shape of the beads. ...

Author(s) : Azhar, M. F.; Haris, M. S.; Mohamad, I.; Ismadi, M. N. S.; Yazid, A. A. H.; Rahman, S. R.; Azlan, N. H.

Publisher : Faculty of Food Science and Technology, Serdang, Malaysia

Journal article : International Food Research Journal 2021 Vol.28 No.4 pp.860-870 ref.36

25. Classification of polymorphic forms of fluconazole in pharmaceuticals by FT-IR and FT-NIR spectroscopy.

The main goal of this work was to test the ability of vibrational spectroscopy techniques to differentiate between different polymorphic forms of fluconazole in pharmaceutical products. These are mostly manufactured with fluconazole as polymorphic form II and form III. These crystalline forms may...

Author(s) : Alaoui Mansouri, M.; Ziemons, E.; Sacré, P. Y.; Kharbach, M.; Barra, I.; Cherrah, Y.; Hubert, P.; Marini, R. D.; Bouklouze, A.

Publisher : Elsevier B.V., Amsterdam, Netherlands

Journal article : Journal of Pharmaceutical and Biomedical Analysis 2021 Vol.196