Search results: 225 results (approx.)

1. Construction and activity evaluation of novel benzodioxane derivatives as dual-target antifungal inhibitors.

Ergosterol exert the important function in maintaining the fluidity and osmotic pressure of fungal cells, and its key biosynthesis enzymes (Squalene epoxidase, SE; 14 α-demethylase, CYP51) displayed the obvious synergistic effects. Therefore, we expected to discover the novel antifungal compounds...

Author(s) : An YunFei; Liu WenXia; Xie HongLei; Fan HaiYan; Han Jun; Sun Bin

Publisher : Elsevier Masson SAS, Issy-les-Moulineaux, France

Journal article : European Journal of Medicinal Chemistry 2022 Vol.227 ref.34

2. Effects of lutein particle size in embedding emulsions on encapsulation efficiency, storage stability, and dissolution rate of microencapsules through spray drying.

Microencapsulation is an effective technique for maintaining stability of labile bioactive components. However, as an indispensable process prior to microencapsulation, the effects of emulsion preparation on microencapsulated products are often overlooked. In this study, three industrialized...

Author(s) : Wang Xiao; Ding Zhuang; Zhao YanNa; Prakash, S.; Liu WenLai; Han Jun; Wang ZhengPing

Publisher : Elsevier Ltd, Oxford, UK

Journal article : LWT - Food Science and Technology 2021 Vol.146

3. Novel naphthylamide derivatives as dual-target antifungal inhibitors: design, synthesis and biological evaluation.

Fungal infections have become a serious medical problem due to the high infection rate and the frequent emergence of drug resistance. Squalene epoxidase (SE) and 14α-demethylase (CYP51) are considered as the important antifungal targets, they can show the synergistic effect on antifungal therapy....

Author(s) : An YunFei; Dong Yue; Liu Min; Han Jun; Zhao LiYu; Sun Bin

Publisher : Elsevier Masson SAS, Issy-les-Moulineaux, France

Journal article : European Journal of Medicinal Chemistry 2021 Vol.210

4. Understanding the rheological properties of a novel composite salecan/gellan hydrogels.

Hydrogel matrixes with diverse adjustable functions have grabbed a lot of attention in the fields of food and biomedicine. However, due to potential biotoxicity, and high energy consumption, chemically crosslinked synthetic hydrogels are typically subjected to certain limitations during their...

Author(s) : Fan ZhiPing; Cheng Ping; Gao Yan; Wang DaWei; Jia GuangWei; Zhang Pan; Prakash, S.; Wang ZhengPing; Han Jun

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Food Hydrocolloids 2021 Vol.123 ref.36

5. Adsorption of lead from aqueous solution by chitosan/rectorite composite sponge.

Rectorite/chitosan (REC/CS) and cross-linked CS composite sponge was prepared by freeze-drying method and characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy and X-ray diffraction. The REC/CS sponge possessed interconnected three-dimensional macropores with pore...

Author(s) : Feng Tao; Wang Shuai; Li PengWei; Hu YiMin; Wang Yu; Han Jun

Publisher : Balaban Publishers - Desalination Publications, Hopkinton, USA

Journal article : Desalination and Water Treatment 2021 Vol.210 pp.340-350

6. Construction and activity evaluation of novel dual-target (SE/CYP51) anti-fungal agents containing amide naphthyl structure.

With the increase of fungal infection and drug resistance, it is becoming an urgent task to discover the highly effective antifungal drugs. In the study, we selected the key ergosterol bio-synthetic enzymes (Squalene epoxidase, SE; 14 α-demethylase, CYP51) as dual-target receptors to guide the...

Author(s) : Liu WenXia; Sun Zhuang; An YunFei; Liu YaTing; Fan HaiYan; Han Jun; Sun Bin

Publisher : Elsevier Masson SAS, Issy-les-Moulineaux, France

Journal article : European Journal of Medicinal Chemistry 2022 Vol.228 ref.36

7. Improved encapsulation efficiency and storage stability of spray dried microencapsulated lutein with carbohydrates combinations as encapsulating material.

Lutein is utilized in food industry as a natural colorant or functional ingredient. Nevertheless, its application is limited by its chemical instability. The aim of this research was to develop and optimize lutein microencapsulated powders (LMPs) by spray drying to enhance storage stability of...

Author(s) : Ding Zhuang; Tao, T.; Yin XiaoHan; Prakash Sangeeta; Wang Xiao; Zhao YanNa; Han Jun; Wang ZhengPing

Publisher : Elsevier Ltd, Oxford, UK

Journal article : LWT - Food Science and Technology 2020 Vol.124

8. Competitive adsorption of heavy metals by anaerobic ammonium-oxidizing (anammox) consortia.

Anammox-based processes and microbial consortia have drawn extensive attention for their use in high-efficiency wastewater treatment technologies. Metals substantially affect the activity of anammox consortia and the quality of wastewater treatment plant effluent. Here, we explored the role of...

Author(s) : Liu YuXia; Han Jun; Dong SiChen; Li YanWei; Liu SiTong; Zhou QingXiang; Chen ChunMao; Alessi, D. S.; Konhauser, K. O.; Zhao HuaZhang

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Chemosphere 2020 Vol.258

9. Potent arylamide derivatives as dual-target antifungal agents: design, synthesis, biological evaluation, and molecular docking studies.

Fungal infections have become a serious medical problem due to the high infection rate and the frequent emergence of drug resistance. Ergosterol is an important structural component of the fungal cell membrane, its synthetases (squalene epoxidase (SE) and 14α-demethylase (CYP51)) are considered as...

Author(s) : Dong Yue; Liu XinYong; An YunFei; Liu Min; Han Jun; Sun Bin

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Bioorganic Chemistry 2020 Vol.99

10. A two-stage desalination process for zero liquid discharge of flue gas desulfurization wastewater by chloride precipitation.

A two-stage desalination process was developed to achieve zero liquid discharge (ZLD) of flue gas desulfurization (FGD) wastewater by precipitating chloride as Friedel's salt. Influential factors for Friedel's salt precipitation, including dosage, reaction time, concentration of sulfate, were...

Author(s) : Xin Yi; Zhou Zhen; Ming Qiang; Sun DongQi; Han Jun; Ye XiaoFang; Dai ShiFeng; Jiang LuMan; Zhao XiaoDan; An Ying

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Journal of Hazardous Materials 2020 Vol.397

11. How to promote rural revitalization via introducing skilled labor, deepening land reform and facilitating investment?

Purpose: This article revealed the difficulties that lie ahead of implementation of the rural revitalization strategy. Design/methodology/approach: This article performed a systematic analysis of the difficulties ahead of implementation of the rural revitalization strategy on the basis of three...

Author(s) : Han Jun

Publisher : Emerald Publishing, Bingley, UK

Journal article : China Agricultural Economic Review 2020 Vol.12 No.4 pp.577-582

12. Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors.

Ergosterol as the core component of fungal cell membrane plays a key role in maintaining cell morphology and permeability. The squalenee epoxidase (SE) and 14-demethylase (CYP51) are the important rate-limiting enzymes for ergosterol synthesis. In the study, these active fragments, which is derived ...

Author(s) : Sun Bin; Dong Yue; An YunFei; Liu Min; Han Jun; Zhao LiYu; Liu XinYong

Publisher : Elsevier Masson SAS, Issy-les-Moulineaux, France

Journal article : European Journal of Medicinal Chemistry 2020 Vol.205

13. Prioritizing agricultural, rural development and implementing the rural revitalization strategy.

Purpose - The purpose of this paper is to identify key missions in the "three nong" domain (i.e. issues related to agriculture, farmers and rural areas in China) that should be successfully accomplished to successfully implement the rural revitalization strategy. Design/methodology/approach -...

Author(s) : Han Jun

Publisher : Emerald Publishing, Bingley, UK

Journal article : China Agricultural Economic Review 2020 Vol.12 No.1 pp.14-19 ref.11

14. Treatment of UASB-treated recycled paper wastewater using SBR and SBBR: A comparison.

Anaerobic-oxic (AO) systems have been extensively adopted for the biological treatment of wastewater from recycled paper mills, which is characterized by high chemical oxygen demand (COD) concentrations and contains hundreds of organic compounds. In this study, an up-flow anaerobic sludge blanket...

Author(s) : Han Jun; Lei LiRong; Cai FangRui; Li YouMing

Publisher : North Carolina State University, College of Natural Resources, Raleigh, USA

Journal article : BioResources 2020 Vol.15 No.2 pp.3473-3486 ref.33

15. Arctiin antagonizes triptolide-induced hepatotoxicity via activation of Nrf2 pathway.

Triptolide (TP) is the most effective ingredient found in the traditional Chinese herbal Tripterygium wilfordii Hook F, and it is widely used in therapies of autoimmune and inflammatory disorders. However, the hepatotoxicity induced by TP has restricted its use in clinical trials. Arctiin is known...

Author(s) : Zhou YuYan; Xia Li; Yao WeiQiang; Han Jun; Wang GuoDong

Publisher : Hindawi, London, UK

Journal article : BioMed Research International 2020 Vol.2020 No.2508952 ref.40

16. Influences of different carbohydrates as wall material on powder characteristics, encapsulation efficiency, stability and degradation kinetics of microencapsulated lutein by spray drying.

In the present study, seven carbohydrates were selected as encapsulant for preparing lutein microencapsulated powders (LMPs). The surface morphology, physical properties, encapsulation efficiency, and thermo- and storage stability of LMPs were studied to determine the protective effects of...

Author(s) : Ding Zhuang; Tao Tao; Wang Xiao; Prakash, S.; Zhao YanNa; Han Jun; Wang ZhengPing

Publisher : Wiley, Oxford, UK

Journal article : International Journal of Food Science & Technology 2020 Vol.55 No.7 pp.2872-2882

17. Development of a fluorescent probe-based real-time reverse transcription recombinase-aided amplification assay for the rapid detection of classical swine fever virus.

Classical swine fever (CSF), which is caused by the CSF virus (CSFV), remains one of the most economically important diseases of the global swine industry. Rapid and reliable detection of CSFV is critical for controlling CSF. In this study, a novel fluorescent probe-based real-time reverse...

Author(s) : Tu Fei; Yang XinTan; Xu ShengKui; Chen DengJin; Zhou Lei; Ge XinNa; Han Jun; Zhang YongNing; Guo Xin; Yang HanChun

Publisher : Wiley, Berlin, Germany

Journal article : Transboundary and Emerging Diseases 2021 Vol.68 No.4 pp.2017-2027 ref.1

18. A strain of porcine deltacoronavirus: genomic characterization, pathogenicity and its full-length cDNA infectious clone.

As a novel enteropathogenic coronavirus, porcine deltacoronavirus (PDCoV) warrants further investigation. In this study, a Chinese PDCoV strain, designated CHN-HN-1601, was isolated from the faeces of a diarrhoeic piglet. After plaque purification, the genome was determined which shared 97.5%-99.5% ...

Author(s) : Zhou XinRong; Zhou Lei; Zhang PingPing; Ge XinNa; Guo Xin; Han Jun; Zhang YongNing; Yang HanChun

Publisher : Wiley, Berlin, Germany

Journal article : Transboundary and Emerging Diseases 2021 Vol.68 No.4 pp.2130-2146

19. Identification of an intramolecular switch that controls the interaction of helicase nsp10 with membrane-associated nsp12 of porcine reproductive and respiratory syndrome virus.

A critical step in replication of positive-stranded RNA viruses is the assembly of replication and transcription complexes (RTC). We have recently mapped the nonstructural protein (nsp) interaction network of porcine reproductive and respiratory syndrome virus (PRRSV) and provided evidence by...

Author(s) : Hu Yunhao; Ke Purui; Gao Peng; Zhang Yongning; Zhou Lei; Ge Xinna; Guo Xin; Han Jun; Yang Hanchun

Publisher : American Society for Microbiology (ASM), Washington, D.C., USA

Journal article : Journal of Virology 2021 Vol.95 No.17 ref.many

20. HRV16 infection induces changes in the expression of multiple piRNAs.

Human rhinovirus (HRV) is one of the most important cold-causing pathogens in humans. Piwi-interacting RNAs (piRNAs) are a recently discovered class of small non-coding RNAs whose best-understood function is to repress mobile element (ME) activity in animal germline. However, the profile of...

Author(s) : Li Jie; Wang XinLing; Wang YanHai; Song Juan; Song QinQin; Wang YanBin; Han Jun

Publisher : Springer Singapore, Singapore, Singapore

Journal article : Virologica Sinica 2021 Vol.36 No.4 pp.736-745 ref.many

21. Evolutionary patterns of codon usage in major lineages of Porcine reproductive and respiratory syndrome virus in China.

Porcine reproductive and respiratory syndrome virus (PRRSV) is economically important and characterized by its extensive variation. The codon usage patterns and their influence on viral evolution and host adaptation among different PRRSV strains remain largely unknown. Here, the codon usage of ORF5 ...

Author(s) : Wu WeiXin; Ge XinNa; Zhang YongNing; Han Jun; Guo Xin; Zhou Lei; Yang HanChun

Publisher : MDPI AG, Basel, Switzerland

Journal article : Viruses 2021 Vol.13 No.6 ref.64

22. Post-discharge oral nutritional supplements with dietary advice in patients at nutritional risk after surgery for gastric cancer: a randomized clinical trial.

Background & aims: Malnutrition frequently occurs and deteriorates in patients after surgery for gastric cancer, especially after hospital discharge, which has been consistently associated with negative outcomes. However, information regarding the impact of post-discharge nutritional...

Author(s) : Meng QingYang; Tan ShanJun; Jiang Yi; Han Jun; Xi QiuLei; Zhuang QiuLin; Wu GuoHao

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Clinical Nutrition 2021 Vol.40 No.1 pp.40-46 ref.38

23. Efficacy of Zhuyu Pill intervention in a cholestasis rat model: mutual effects on fecal metabolism and microbial diversity.

Cholestasis is a clinical condition resulting from impaired bile flow. Currently, patients with cholestasis face several barriers in seeking diagnosis and treatment. Zhuyu Pill (ZYP) is an ancient classic formula of the Coptis-Evodia herb couples (CEHC), and has been used for cholestasis treatment...

Author(s) : Yu Han; Liu Chao; Zhang FengHua; Wang JianFei; Han Jun; Zhou Xin; Wen YueQiang; Shen Tao

Publisher : Frontiers Media S.A., Lausanne, Switzerland

Journal article : Frontiers in Pharmacology 2021 Vol.12 No.September ref.56

24. Anti-inflammatory effects of kaempferol-3-O-rhamnoside on HSV-1 encephalitis in vivo and in vitro.

Background: Herpes simplex virus encephalitis (HSE) is an acute central nervous system infectious disease caused by herpes simplex virus (HSV). Currently, there is no effective treatment for HSE infection, which produces many pro-inflammatory factors. Kaempferol-3-O-rhamnoside (K-3-rh) is a plant...

Author(s) : Zhao ChaoYang; Wang Fen; Tang BoLin; Han Jun; Li Xiang; Lian Guo; Li XiaoLong; Hao ShiSheng

Publisher : Elsevier Science Ireland Ltd., Shannon, Irish Republic

Journal article : Neuroscience Letters 2021 Vol.765 ref.49

25. miRNA and miRNA target genes in intervention effect of Zhuyu pill on cholestatic rat model.

Ethnopharmacological relevance: Zhuyu pill (ZYP), an effective prescription of traditional Chinese medicine, is composed of Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley and has shown potential anticholestatic effects. However, its mechanism of action in treating...

Author(s) : Yu Han; Liu Chao; Wang JianFei; Han Jun; Zhang FengHua; Zhou Xin; Wen YueQiang; Shen Tao

Publisher : Elsevier Ltd, Oxford, UK

Journal article : Journal of Ethnopharmacology 2021 Vol.283 ref.59