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  • Interactive effects of peripheral and central administration of LPS with inhibition of CRF receptors on food intake in neonatal chicks.

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    Author(s) : Kooshki, R.Abbasnejad, M.Jonaidi, H.Soltaninejad, M.Sharifimehr, A.Yosoufi, M.Aghapour, M.

    Author Affiliation : Group of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.

    Author Email : hjonaidi@uk.ac.ir

    Journal article : Iranian Journal of Veterinary Science and Technology 2019 Vol.11 No.1 pp.19-25, 64 ref.51

    Abstract : AnorexiaanorexiaSubject Category: Diseases, Disorders, and Symptoms
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    is a part of the acute phase response (APR). Lipopolysaccharide (LPS) is frequently used to mimic APR and induces anorexia. The mechanism underlying anorexia associated with APR in chickschicksSubject Category: Organism Groups
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    is not well understood. In the present study, the possible involvement of corticotrophin-releasing factor (CRF) on anorexic effects of LPS in neonatal chicks was investigated. For this aim, different doses of LPS were administrated via both intracerebroventricular (ICV) and intraperitoneal (IP) routes in order to assess its effects on chick's food intake. Subsequently, the effect of ICV injection of astressin, a CRF receptor antagonist, on anorexia induced by ICV and IP administration of LPS was investigated. Food intake was significantly decreased following either central or systemic administration of LPS. ICV co-injection of astressin and LPS significantly diminished anorexic effects of central LPS. However, anorexia induced by peripheral LPS was not attenuated by central injection of astressin. These data indicated that the brain CRF receptors are involved in central LPS-induced anorexia in chicks.

    ISSN : 2008-465X

    URL : https://ijvst.um.ac.ir/.../76494

    Record Number : 20193361875

    Publisher : Ferdowsi University of Mashhad

    Location of publication : Mashhad

    Country of publication : Iran

    Language of text : English

    Language of summary : Persian

    Indexing terms for this abstract:

    Descriptor(s) : anorexiaanorexiaSubject Category: Diseases, Disorders, and Symptoms
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    , antagonistsantagonistsSubject Category: Chemicals and Chemical Groups
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    , chickschicksSubject Category: Organism Groups
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    , corticoliberincorticoliberinSubject Category: Chemicals and Chemical Groups
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    , dosage effectsdosage effectsSubject Category: Properties
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    , feed intakefeed intakeSubject Category: Properties
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    , lipopolysaccharideslipopolysaccharidesSubject Category: Chemicals and Chemical Groups
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    , pharmacodynamicspharmacodynamicsSubject Category: Miscellaneous
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    Identifier(s) : corticotropin releasing factor, corticotropin releasing hormone, drug action, inappetence, mechanism of drug action